Results: 2

1.
Figure 2

Figure 2. From: Hesperetin, a Potential Therapy for Carcinoid Cancer.

A. Western blot analysis of hesperetin’s effects on Notch1 protein level demonstrates minimal Notch1 in DMSO (control) treated cells. After a 2 day treatment of 50 μM and 100 μM hesperetin, Notch1 protein expression is increased. B. Expression of Notch1 relative mRNA levels was measured with qPCR after treatment of BON cells with 50 μM and 100 μM hesperetin. At baseline, BON cells exhibit minimal Notch1 mRNA. After treatment, Notch1 relative mRNA levels are increased 1000 fold with a 50 μM treatment of hesperetin and 4000 fold with a 100 μM dose.

Barbara Zarebczan, et al. Am J Surg. ;201(3):329-333.
2.
Figure 1

Figure 1. From: Hesperetin, a Potential Therapy for Carcinoid Cancer.

A. Cell proliferation analysis of BON cells treated with DMSO (control) or 25 to 125 μM hesperetin for up to 6 days. BON cell growth was inhibited compared to the control beginning with a 50 μM dose. B. Western blot analysis of neuroendocrine tumor markers was performed on BON cells treated with DMSO (control) or 50 to 100 μM hesperetin for 2 and 4 days. ASCL1 expression was inhibited by both 50 μM and 100 μM doses after 4 days of treatment. CgA expression was inhibited by both treatments after 2 days of treatment when compared to controls. All samples were loaded equally as shown by β-actin.

Barbara Zarebczan, et al. Am J Surg. ;201(3):329-333.

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