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Figure 1. From: Depressive Symptoms, Brain Volumes and Subclinical Cerebrovascular Disease in Postmenopausal Women: The Women's Health Initiative MRI Study.

Adjusted mean middle frontal gyrus (A) and superior frontal gyrus (B) volumes and 95% confidence interval after fully adjusting for potential confounding variables.*
Footnote: *Confounding variables: Women’s Health Initiative clinical trial, arm, clinical site, age, race/ethnicity, education, body mass index, modified mini-mental state (3MS), smoking, prior use of hormone therapy, antidepressant therapy, cardiovascular disease history, diabetes, hypertension, intracranial volume, and time from randomization to magnetic resonance imaging (MRI) scan

Joseph S. Goveas, et al. J Affect Disord. ;132(1-2):275-284.

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