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Results: 4

1.
Figure 4

Figure 4. From: Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases.

Molecular mechanisms of immunity to mycobacteria revealed by immunogenetic studies.

Hui-Qi Qu, et al. Int J Infect Dis. ;15(5):e305-e313.
2.
Figure 1

Figure 1. From: Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases.

The proteins involved in interferon-gamma (IFN-γ) signaling. Without the binding of IFN-γ, the IFN-γ receptor subunits are not associated with each other. IFNγR1 binds with JAK-1, and IFNγR2 binds with JAK-2. STAT1 exists in the cytoplasm as a homodimer through the interaction of N-terminal domains.

Hui-Qi Qu, et al. Int J Infect Dis. ;15(5):e305-e313.
3.
Figure 2

Figure 2. From: Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases.

The critical components involved in interleukin-12 (IL-12) signaling. IL12R.β1 is associated with TYK-2, and IL12Rβ2 is associated with JAK-2. STAT4 exists in the cytoplasm as a homodimer through the interaction of the N-terminal domains. The active form of STAT4 is a tetramer.

Hui-Qi Qu, et al. Int J Infect Dis. ;15(5):e305-e313.
4.
Figure 3

Figure 3. From: Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases.

Nuclear factor kappa B essential modulator (NEMO) and NF-κB activation. NEMO is a critical regulatory component of IκB kinase (IKK), which receives cell surface signals and activates the IKK catalytic subunits Ikk-1 and Ikk-2. Activated IKK phosphorylates IκB, and induces the degradation of IκB. Released by the inhibitory IκB, active NF-κB dimer translocates to the nucleus and regulates the transcription of target genes.

Hui-Qi Qu, et al. Int J Infect Dis. ;15(5):e305-e313.

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