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Results: 5

1.
Fig. 4

Fig. 4. From: Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson's Disease.

Organ doses (μGy/MBq) to the critical organs in control subjects (small intestine) and to patients with WD (liver). Doses for females are higher than those for males. Error bars indicate the standard deviation (SD) for N=4 independent experiments.

Fangyu Peng, et al. Mol Imaging Biol. ;14(1):70-78.
2.
Fig. 5

Fig. 5. From: Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson's Disease.

Total PET dose from a 64CuCl2 PET scan in both genders for control subjects and patients with WD (injected activity 5 MBq/kg). The doses for females are higher than those for males. Error bars indicate the standard deviation (SD) for N=4 independent experiments.

Fangyu Peng, et al. Mol Imaging Biol. ;14(1):70-78.
3.
Fig. 3

Fig. 3. From: Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson's Disease.

Comparison of the %ID/g at 24 h post-injection in several organs of Atp7b−/− knock-out (KO) and C57BL wild-type (WT) mice. In the liver, the %ID/g of KO mice was significantly higher than that in the WT mice, whereas in all other organs the %ID/g was significantly lower in the KO mice, except for the lungs where the difference was not significant (see text).

Fangyu Peng, et al. Mol Imaging Biol. ;14(1):70-78.
4.
Fig. 2

Fig. 2. From: Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson's Disease.

Time-activity plots of 64Cu radioactivity distribution in the mice post intravenous injection with 64CuCl2. Decay corrected time–activity curves were obtained from average of 64Cu radioactivity at various time points (minutes) post intravenous injection of 64CuCl2 in mice [KO, ATP7b−/− knock-out mice (N=4) and WT, wild type C57BL mice (N=4)]. Hepatic uptake of 64Cu in the Atp7b−/− mice is higher than that by the control C57BL mice, with continuing accumulation of 64Cu in the Atp7b−/− mice. Following rapid decrease of 64Cu radioactivity from blood pool, tracer concentrations in the lungs and heart are stable, with relatively low tracer uptake in the brain in the Atp7b−/− and control C57BL mice. Initial renal uptake of 64Cu in the control C57BL mice is higher than that in the ATP7b−/− mice. Subsequently, 64Cu radioactivity in the kidneys of the control C57BL mice has gradually decreased to the similar level in the ATP7b−/− mice.

Fangyu Peng, et al. Mol Imaging Biol. ;14(1):70-78.
5.
Fig. 1

Fig. 1. From: Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson's Disease.

Representative PET-CT images of Atp7b−/− mice injected with 64CuCl2 intravenously. Whole body PET-CT images of an Atp7b−/− mouse and a wild-type C57BL mouse were obtained during the first hour by dynamic imaging (0–1 h), and static at 2 and 24 h post-injection (p.i.) of 64CuCl2, respectively. On the images obtained during the first hour post-injection, intense 64Cu radioactivity was seen in the liver of Atp7b−/− and wild-type mice, with much less radioactivity in the muscle and brain. Diffuse radioactivity in the abdomen represents 64Cu radioactivity in the intestinal tracts resulted from hepatobilliary clearance. At 2 and 24 h post-injection, intense 64Cu radioactivity remained in the liver of Atp7b−/− mouse, in contrast to reduced 64Cu radioactivity in the liver of wild-type C57BL mice. There is little 64Cu radioactivity in the urinary bladder, which indicates that 64Cu is mainly cleared through hepatobilliary clearance pathway. MIP (maximum intensity projection), Scale bar %ID/g (percentage of injected dose per gram).

Fangyu Peng, et al. Mol Imaging Biol. ;14(1):70-78.

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