Results: 2

1.
Fig. 1.

Fig. 1. From: Immunotypes of a Quaternary Site of HIV-1 Vulnerability and Their Recognition by Antibodies.

Analysis of 2909 and PG16 neutralization of 80 wild-type (left; solid lines) and N160K mutant (right; dashed lines) HIV-1 Env pseudoviruses from clades A, B, and C. Dendrograms, made by the neighbor-joining method, show the wild-type envelope protein sequence distance. The clade B strain HXB2 was used to root the tree. The clades of HIV-1 are indicated, and the amino acid distance scale is indicated with a value of 1% distance as shown. The neutralization potencies of 2909 and PG16 are indicated by the color of the branch for each virus. The 160K mutant data for viruses 89.6, 6101.10, QH0692.42, and BR07 are shown in the N160K mutant dendrograms, although these isolates did not have an asparagine at position 160. Viruses SF162, BL01, and ZM214.15 each have a wild-type 160K residue, and they are included among the viruses in the wild-type dendrograms; the data for the converse K160N mutation are shown in the N160K mutant dendrograms. For JR-FL variants, the JR-FL_E168K data are shown in the wild-type dendrograms and the JR-FL_N160K_E168K data are shown in the N160K mutant dendrograms.

Xueling Wu, et al. J Virol. 2011 May;85(9):4578-4585.
2.
Fig. 2.

Fig. 2. From: Immunotypes of a Quaternary Site of HIV-1 Vulnerability and Their Recognition by Antibodies.

Analysis of correlations between 2909 and PG16 or PG9 neutralization sensitivities among 80 HIV-1 Env pseudoviruses. (A) Contingency tables show the relationships between viral sensitivities to 2909 and PG16 (upper panel) and to 2909 and PG9 (lower panel). The viruses were tested with 160N for PG16 and PG9 sensitivity and with 160K for 2909 sensitivity. A virus with a 50% inhibitory concentration (IC50) of ≤50 μg/ml was considered to be sensitive. Fisher's exact test was used to determine the significance of the correlations. (B) Neutralization IC50 values of PG16 (left) and PG9 (right) are plotted for 2909-sensitive (n = 23) and 2909-resistant (n = 57) strains. The geometric mean for each group is indicated with a horizontal bar. The unpaired Student t test was used to determine the significance of the difference between the geometric means for the 2909-sensitive and 2909-resistant strains.

Xueling Wu, et al. J Virol. 2011 May;85(9):4578-4585.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk