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Results: 4

1.
Figure 2

Figure 2. From: Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection.

Modes of E. coli O157:H7 transmission to humans with emphasis on strategies for prevention/intervention. Other modes of transmission of E. coli O157:H7 have been reported and are described elsewhere.

Krystle L. Mohawk, et al. J Biomed Biotechnol. 2011;2011:258185.
2.
Figure 1

Figure 1. From: Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection.

Major outbreaks of E. coli O157:H7 infection. Outbreaks are listed by year and in the context of key discoveries that linked Stx with development of HUS.

Krystle L. Mohawk, et al. J Biomed Biotechnol. 2011;2011:258185.
3.
Figure 3

Figure 3. From: Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection.

E. coli O157:H7 virulence factor expression and interaction with host cells. E. coli O157:H7 possesses a large plasmid (pO157), carries the LEE PAI (and thus is intimin positive), and expresses Shiga toxins. The LEE locus encodes a TTSS and TTSS effector proteins. One of the TSSS proteins, E. coli Secreted Protein (Esp) A, forms a filament that serves to translocate TTSS effector proteins from the bacterium into the host cell by way of a pore created by EspB and EspD. One of these effectors, Tir, serves as the receptor for the major adhesin, intimin, and thus allows adherence of the bacterium to the host cell.

Krystle L. Mohawk, et al. J Biomed Biotechnol. 2011;2011:258185.
4.
Figure 4

Figure 4. From: Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection.

Model of the role of Stx2 in E. coli O157:H7 adherence and colonization. (a) E. coli O157:H7 elaborates Shiga toxin early during the colonization/adherence process. Stx2 exerts an effect on the host cell epithelium that leads to increased levels of cell surface-localized nucleolin. Nucleolin acts as an initial receptor for intimin, an interaction that allows E. coli O157:H7 to bind to the host epithelium and inject Tir and other TTSS effectors into the host cell. Intimin then engages Tir which, coupled with the cellular effects of other TTSS effectors, leads to host cell cytoskeletal rearrangement and formation of the characteristic A/E lesion. (b) Stx2, produced by the wild-type organism or provided to a stx2 mutant, facilitates colonization of the gastrointestinal tract. (c) Neutralizing anti-Stx2 antibody present prior to and during E. coli O157:H7 infection results in reduced levels of E. coli O157:H7 colonization of the gastrointestinal tract.

Krystle L. Mohawk, et al. J Biomed Biotechnol. 2011;2011:258185.

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