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Results: 9

1.
Figure 5

Figure 5. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

Evoked EPSCs and PPRs in BACHD mice at 2 months. A. PPRs are significantly decreased in D1-BACHD compared to D1-WT cells at 2 months. In contrast, PPRs are similar in D2-BACHD and D2-WT cells. B. Evoked EPSC amplitudes are significantly increased in D2-BACHD compared to D2-WT cells while they are similar in D1-BACHD and D1-WT cells.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.
2.
Figure 3

Figure 3. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

Excitatory synaptic transmission in D2-YAC128 cells. A. Mean sEPSC frequency was not different in D2-YAC128 and D2-WT cells at any age. Cumulative probability distributions of inter-event intervals only showed slight differences at 12 months when D2-YAC128 cells displayed significantly fewer sEPSCs, at the longer intervals only. B. Mean mEPSC frequency (inset) and cumulative probability distribution of inter-event intervals for mEPSCs were not different at 1.5 months for D2-YAC128 and D2-WT cells. C. PPRs were not different in D2-YAC128 cells compared to D2-WT cells at each age tested.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.
3.
Figure 2

Figure 2. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

Biphasic alterations of excitatory synaptic transmission in D1-YAC128 cells. A. Mean sEPSC frequency and cumulative probability distributions of inter-event interval histograms for sEPSCs show that D1-YAC128 cells display higher sEPSC frequencies at 1.5 months, while at 12 months D1-YAC128 cells display lower sEPSC frequencies. B. Mean mEPSC frequency (inset) and cumulative probability distribution of inter-event intervals for mEPSCs at 1.5 months show that D1-YAC128 cells display a significantly higher mEPSC frequency. C. PPRs were significantly decreased in D1-YAC128 cells at 1.5 months, indicating increased glutamate release probability. In contrast, PPRs were increased in D1-YAC128 cells at 12 months, indicating decreased probability of glutamate release.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.
4.
Figure 4

Figure 4. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

Mean amplitude of evoked EPSCs is increased in D2-YAC128 cells at 1.5 months and decreased at 12 months in D1-YAC128 cells. A. Traces show evoked EPSCs to stimulation in WT (black) and YAC128 (red) at 1.5 and 12 months. Numbers above traces are stimulus intensities. B. Input-output functions show evoked EPSCs at the two ages in WT cells. Currents increase significantly with age in D1 cells but show no change in D2 cells. C. At 1.5 months, evoked EPSC amplitudes are similar in D1-YAC128 compared to D1-WT cells while at 12 months, evoked EPSC amplitudes are decreased in D1-YAC128 cells compared to D1-WT cells. D. At 1.5 months, evoked EPSC amplitudes are increased in D2-YAC128 compared to D2-WT cells while at 12 months, they are similar.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.
5.
Figure 1

Figure 1. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

Frequency of sEPSCs varies differentially with age in D1 and D2 cells in WTs. A. Traces show sEPSCs in D1- and D2-WT cells at 1.5, 6 and 12 months. B. Graph shows that the mean frequency of sEPSCs increases with age in D1 while it decreases with age in D2 cells. At 1.5 months, sEPSC frequency was significantly higher in D2 cells while at 12 months, it was significantly higher in D1 cells. C. Cumulative probability distributions of inter-event intervals in D1-WT cells show intervals significantly decrease at 6 and 12 months compared to 1.5 months. D. Cumulative probability distributions of inter-event intervals in D2-WT cells show intervals significantly increase at 12 months compared to 1.5 and 6 months. Numbers of cells per group in parentheses, * indicates p<0.05 and ** indicates p<0.01 in this and other figures.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.
6.
Figure 9

Figure 9. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

A. Photomicrographs of immunofluorescent staining for NeuN (red) combined with EGFP in D1 (top row) or D2 cells (bottom row), at 1.5 (2 left columns) and 12 (2 right columns) months in the dorsal striatum of WT and YAC128 mice. Pictures show overlay of EGFP and NeuN, in which cells expressing both appear yellow. B. Bar graph of neuronal (NeuN) densities at both ages do not show any differences between WT and YAC128 mice. C. Bar graph shows the ratio of EGFP-positive neurons does not change between WT and YAC128 mice at any age. There are more D1-EGFP positive than D2-EGFP positive neurons at 1.5 months. * indicates p<0.05 between D1-and D2-EGFP neurons.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.
7.
Figure 6

Figure 6. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

DA modulation of sEPSCs in D1 and D2 cells is altered in YAC128 mice. A. Traces show that at 1.5 months, the D1 receptor agonist SKF81297 increased sEPSC frequency in D1-WT cells while it had no effect in D1-YAC128 cells. In contrast at 12 months, SKF81297 increased the frequency of sEPSCs. B. Traces show that at 1.5 months, the D2 receptor agonist quinpirole decreases sEPSCs in D2-WT cells but not in D2-YAC128 cells. At 12 months, the D2 receptor antagonist remoxipride increases sEPSC frequency in D2-WT cells but not in D2-YAC128 cells. C. Bar graphs show the percent changes in sEPSC frequency in D1 and D2 cells in WT and YAC128 mice at three ages.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.
8.
Figure 8

Figure 8. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

Locomotor activity in YAC128 and BACHD mice. A. YAC128 mice at 6 and 12 months displayed decreased distance traveled during 15 min in the open-field apparatus compared to WT mice. In WT and YAC128 mice, the distance traveled slightly decreased with age. In WT mice at 12 months, distance traveled was lower than that at 1.5 and 6 months. In YAC128 mice, distance was significantly decreased at 12 compared to 6 months. B. 1.5 and 6 month old YAC128 mice showed more stereotypies than WT mice while at 12 months, stereotypies were similar in WT and YAC128 mice. The number of stereotypic movements decreased with age in YAC128 mice. C. In 2 month-old BACHD mice, distance traveled was significantly lower than in the WT mice. D. BACHD mice display more stereotypies, more grooming (E) and more sniffing (F) than WT mice. G. TBZ (2.5 mg/kg) decreased distance traveled during 15 min in the open-field apparatus in 2 month old WT and BACHD mice and the percent decrease was similar in WT and BACHD mice. H. TBZ did not have any effect on stereotypies in WT mice while it decreased them in BACHD mice. * indicates p<0.05 and ** indicates p<0.01 in YAC128 (or BACHD) compared to WT mice at each age. # indicates p<0.05 in WT mice at different ages. § indicates p<0.05 in YAC128 mice at different ages.^ indicates p<0.05 before and after TBZ treatment.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.
9.
Figure 7

Figure 7. From: Differential electrophysiological changes in striatal output neuronsin Huntington's disease.

A. Effect of TBZ on sEPSC frequency in D1-WT and D1-YAC128 cells at 1.5 months. In D1-WT cells, TBZ induced a transient but significant increase in sEPSC frequency at 5 min while at 40, 50 and 65 min TBZ induced a significant decrease in sEPSC frequency. In D1-YAC128 cells, TBZ did not increase sEPSC frequency but induced a larger decrease than in D1-WT cells at 25, 40, 50 and 65 min. B. In YAC128 slices (1.5 months) incubated for 2–4 h in TBZ, the D1 receptor agonist SKF81297 (5 μM) induced a significant increase in frequency of sEPSCs in D1 cells while in YAC128 incubated in DMSO, SKF81297 had no effect. The effect of SKF81297 was significantly different between DMSO and TBZ treatment. C. In 2 month old BACHD mice, in TBZ-incubated slices, D1 cells showed PPRs higher than those in DMSO-incubated slices, similar to PPRs in D1-WT cells. D. Traces and graphs show sEPSC frequency is higher in D1-BACHD cells (2 months) than in D1-WT cells. In addition, the D1 agonist SKF81297 increased sEPSC frequency in D1-WT cells but not in D1-BACHD cells. E. Amplitude-frequency histogram shows that in D1-WT cells, the D1 antagonist SCH23390 (20 μM) had no effect on sEPSC frequency. F. In contrast, in D1-BACHD cells, the D1 antagonist decreased sEPSC frequency. Inset shows that the percent change induced by SCH23390 is significantly different in D1-WT and D1-BACHD cells. * indicates p<0.05, ** indicates p<0.01. *** indicates p<0.001 effect of TBZ compared to control (0 min in TBZ). # indicates p<0.05 and ### indicates p<0.001 in D1-YAC128 (or D1-BACHD) compared to D1-WT cells. * indicates p<0.05 in TBZ-treated vs DMSO-treated slices.

Véronique M. André, et al. J Neurosci. ;31(4):1170-1182.

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