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Results: 3

1.
Figure 1

Figure 1. From: New insights into HIV-1-primary skin disorders.

HIV-1-driven immunological changes in the skin. Graphic representation of the immunological processes involved in the pathogenesis of primary HIV-1 related skin disorders, highlighting the presentation of the virus by a dendritic cell to a CD4+ T lymphocyte and the subsequent changes in the cytokine profile that are brought by the death of Th1 cells.

Filiberto Cedeno-Laurent, et al. J Int AIDS Soc. 2011;14:5-5.
2.
Figure 3

Figure 3. From: New insights into HIV-1-primary skin disorders.

Human endogenous retroviruses and their hypothetical role in psoriasis. During HIV-1 infection, HIV-1 tat protein acts as a trans-acting factor activating HERV's long terminal repeat (LTR). Stimulation of the trans-activation region (TAR) by its interaction with the HIV-1 tat protein activates transcription. Subsequently, exogenous retroviruses trigger an immune response, and HERV-encoded proteins are recognized as self-antigens (molecular mimicry) awakening a cellular-based autoimmune phenomenon.

Filiberto Cedeno-Laurent, et al. J Int AIDS Soc. 2011;14:5-5.
3.
Figure 2

Figure 2. From: New insights into HIV-1-primary skin disorders.

HIV-1 primary skin disorders. A) Patient with seborrheic dermatitis showing a papulosquamous disorder patterned on the sebum-rich areas of the scalp and face. B) Representative section (H&E 20x) shows focal parakeratosis, moderarte acanthosis, spongiosis related to hair follicles and scarce neutrophils. C) Patient with atopic dermatitis with lesions ranging from weeping crusted areas to lichenified plaques. D) Representative section (H&E 20x) shows acanthosis, mild spongiosis, and dermal infiltrate composed of lymphocytes, monocytes and few eosinophils. E) Patient with psoriasis, characterized by symmetric raised inflamed lesions covered with a silvery white scale in both lower limbs. F) Representative section (H&E 10x) shows hyperkeratosis, parakeratosis, acanthosis, spongiosis, absence of granulosum layer and neutrophil infiltrates (Munro's microabscess). G) Patient with eosinophilic folliculitis featured by follicular pustular papules on the upper part of the chest. H) Representative section (H&E 20x) shows perifollicular and perivascular infiltrate with eosinophils.

Filiberto Cedeno-Laurent, et al. J Int AIDS Soc. 2011;14:5-5.

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