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2.
Figure 2

Figure 2. Haplotype association mapping was used to identify SNPs that associated with TST phenotype.. From: Phenotypic Characterization of a Genetically Diverse Panel of Mice for Behavioral Despair and Anxiety.

(A) Three SNPs, one on MMU10 and 2 adjacent SNPs on MMU9, exceeded the significance threshold (gFWER-adjusted p<0.05). Individual SNP logP values are plotted against cumulative genomic position (bp). P value thresholds are derived from gFWER calculations. (B) Haplotype block pattern at the significant MMU9 locus. Strains are plotted along the x-axis from smallest to largest TST percent immobility; haplotype group is indicated by color/number. All significant and suggestive loci consisted of a core set of ∼5 unrelated, low-immobility strains.

Brooke H. Miller, et al. PLoS One. 2010;5(12):e14458.
3.
Figure 3

Figure 3. Mouse: human synteny at the MMU10 locus.. From: Phenotypic Characterization of a Genetically Diverse Panel of Mice for Behavioral Despair and Anxiety.

(A) Ideogram maps of MMU10 and HSA12. The MMU10 locus (in red) is syntenic to a region on HSA12 (blue) that has been linked to both major depression and bipolar disorder. The brain-expressed gene Socs2 lies within this locus in both mice and humans. (B) Resequencing identified an A/G polymorphism in the putative promoter region upstream to the Socs2 transcriptional start site. The “A” allele is carried by the low TST immobility haplotype group, while the “G” allele is found in the haplotype group consisting of higher immobility strains. (C) The difference in average TST values between the “A” and “G” haplotypes is highly significant (p = 5.97−10).

Brooke H. Miller, et al. PLoS One. 2010;5(12):e14458.

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