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Results: 3

1.
Figure 1

Figure 1. From: Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

Regional association plots around the ATM locus for the logistic regression analysis. The solid and open triangles are from directly typed and imputed SNPs respectively

Kaixin Zhou, et al. Nat Genet. ;43(2):117-120.
2.
Figure 2

Figure 2. From: Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

Effect of KU-55933 on AMPK activation by metformin
H4IIE cells were pre-treated with or without 10 μM KU-55933 for 30 min and then with various concentrations of metformin for 1 hr, and AMPK activity measured; Results are mean ± S.D. (n = 2); **significantly different from incubation without KU-55933 by 2-way ANOVA (p<0.01).

Kaixin Zhou, et al. Nat Genet. ;43(2):117-120.
3.
Figure 3

Figure 3. From: Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

A Western Blot comparing the phosphorylation status of Thr-172 of AMPK and Ser-79 of ACC (a well characterized marker of AMPK activation). H4IIE cells were pre-treated with or without 10 μM KU-55933 (KU) for 1 hour and then for 3 hours with or without 2.5mmol/L metformin. Metformin induced phosphorylation of AMPK and subsequent phosphorylation of ACC was partially reduced by KU-55933.

Kaixin Zhou, et al. Nat Genet. ;43(2):117-120.

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