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Figure 1

Figure 1. From: Cooperative regulatory events and Foxp3 expression.

Transcriptional regulation of Foxp3. (a) Structure of mouse Foxp3. Boxes indicate exons (numbers above). (b) Location of the Foxp3 promoter, enhancers (1 and 2) and CNS3 regions, as well as exons −2a, −2b, −1 and 1. Binding regions for regulators of Foxp3 transcription are above (negative regulators) and below (positive regulators). This model is based on many publications.

Masahide Tone, et al. Nat Immunol. ;12(1):14-16.

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