Results: 2

1.
Figure 1

Figure 1. From: HIGH COLORECTAL AND LOW ENDOMETRIAL CANCER RISK IN EPCAM DELETION-POSITIVE LYNCH SYNDROME: A COHORT STUDY.

Cancer risk in EPCAM deletion carriers. Cumulative risk until the age of 70 of colorectal cancer (A) and endometrial cancer (B) in EPCAM (black lines), EPCAM-MSH2 (pink lines), MSH2 (red lines), MSH6 (green lines), and MLH1 (blue lines) mutation carriers. Indicated log-rank p-values are comparisons relative to EPCAM deletion carriers. The number of subjects in the table below the graphs indicate the number of mutation carriers, that are at risk for their first colorectal (A) or endometrial cancer (B) at the given age. Eight EPCAM deletion carriers were excluded from the Kaplan Meier curves because the exact age at colorectal cancer diagnosis (n=2) or at follow up (n=6) were unknown.

Marlies JE Kempers, et al. Lancet Oncol. ;12(1):49-55.
2.
Figure 2

Figure 2. From: HIGH COLORECTAL AND LOW ENDOMETRIAL CANCER RISK IN EPCAM DELETION-POSITIVE LYNCH SYNDROME: A COHORT STUDY.

Cancer risk in EPCAM deletion carriers in relation to deletion breakpoint and size. (A) Schematic representation of the size of each EPCAM deletion (depicted by bars) and its position relative to the MSH2 CpG island (CGI) promoter. The deletions found in the endometrial cancer patients are depicted in black, the others are presented in grey. For each deletion the number of carriers as well as the number of patients with colorectal cancer (CRC) or endometrial cancer (EC) are indicated on the left. ST: subtotal; T: total. The cumulative colorectal (B) and endometrial (C) cancer risk of subgroup 1 (grey lines), subgroup 2 (black lines) in comparison to those of MSH2 (red lines) and MSH2-EPCAM (bleu lines) mutation carriers. Indicated log-rank p-values are comparisons relative to MSH2 mutation carriers. The number of subjects in the table below the graphs indicate the number of mutation carriers, that are at risk for their first colorectal (B) or endometrial cancer (C) at the given age. Eight EPCAM deletion carriers were excluded from the Kaplan Meier curves because the exact age at colorectal cancer diagnosis (n=2) or at follow up (n=6) were unknown.

Marlies JE Kempers, et al. Lancet Oncol. ;12(1):49-55.

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