Results: 4

1.
Figure 2

Figure 2. Net inter-compartmental flows of VEGF, anti-VEGF and VEGF/anti-VEGF complex. From: Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model.

Solid line: normal tissue; dotted line: tumor. Black: free VEGF; light gray: anti-VEGF agent; dark gray: VEGF/anti-VEGF complex (also total VEGF).

Marianne O. Stefanini, et al. Cancer Res. ;70(23):9886-9894.
2.
Figure 4

Figure 4. VEGF receptor occupancy profiles. From: Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model.

Percentage of ligated and unligated receptors. A. VEGFR1, B. VEGFR2, C. NRP1. Solid line: normal tissue; dotted line: tumor. Black: single injection; gray: metronomic therapy.

Marianne O. Stefanini, et al. Cancer Res. ;70(23):9886-9894.
3.
Figure 1

Figure 1. Free VEGF concentration profiles following the intravenous injection of an anti-VEGF agent. From: Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model.

A-B. Single injection (10 mg/kg), C-D. Daily injection of 1 mg/kg for 10 days (metronomic therapy). 1 pM VEGF equivalent to 24 pg/mL total blood. Solid line: normal tissue; dashed line: blood; dotted line: tumor.

Marianne O. Stefanini, et al. Cancer Res. ;70(23):9886-9894.
4.
Figure 3

Figure 3. Relative VEGF distribution profiles in normal, blood and tumor tissues. From: Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model.

Percentage of VEGF bound to the anti-VEGF agent, free, bound to the receptors and sequestered in the extracellular matrix. From top to bottom: normal tissue, blood, tumor. Light gray: VEGF bound to anti-VEGF (VEGF/anti-VEGF complex); white: VEGF bound to the extracellular matrix; dark gray: VEGF bound to receptors; black: unbound VEGF.

Marianne O. Stefanini, et al. Cancer Res. ;70(23):9886-9894.

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