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Results: 3

1.
Figure 3.

Figure 3. From: Longitudinal Study of Cone Photoreceptors during Retinal Degeneration and in Response to Ciliary Neurotrophic Factor Treatment.

Cone photoreceptor tracking using AOSLO. (A) Individual cones (red crosses) are visible within a mosaic in a normal subject at baseline (top) and 53 months later (bottom). Yellow circles: cones (8/1906 or 0.4%) that were not seen 53 months later. (B) Individual cones are visible within a mosaic in the CNTF-treated eye of patient 3 at baseline (top), 20 months (middle), and 32 months (bottom) and show no loss over 32 months.

Katherine E. Talcott, et al. Invest Ophthalmol Vis Sci. 2011 April;52(5):2219-2226.
2.
Figure 2.

Figure 2. From: Longitudinal Study of Cone Photoreceptors during Retinal Degeneration and in Response to Ciliary Neurotrophic Factor Treatment.

Cone photoreceptor density using AOSLO. Examples of paired AOSLO images at baseline and post-treatment in patient 1 sham (A) and CNTF-treated (B), patient 2 sham (C) and CNTF-treated (D), and patient 3 CNTF-treated (F) eyes in which cone density measurements were made (yellow squares, Fig. 1). Red dots: cones identified for density analysis. (E) Cone density over time in sham (red, n = 9) and CNTF-treated (blue) eyes (n = 12). Solid lines: patient 1; long dashed line: patient 2; short dashed lines: patient 3; gray bar: measurement error (±6.3%).

Katherine E. Talcott, et al. Invest Ophthalmol Vis Sci. 2011 April;52(5):2219-2226.
3.
Figure 1.

Figure 1. From: Longitudinal Study of Cone Photoreceptors during Retinal Degeneration and in Response to Ciliary Neurotrophic Factor Treatment.

Retinal and AOSLO images. For each patient, fundus photographs are shown with AOSLO images and foveal horizontal spectral-domain optical coherence tomography (OCT) scans superimposed (horizontal lines: OCT scan location; white squares on AOSLO images: ROIs where cone spacing was analyzed in each AOSLO image over 30 months; yellow squares: retinal locations of density examples shown in Fig. 2). (A) Sham-treated and CNTF-treated eyes of patient 1. (B) Sham-treated and CNTF-treated eyes of patient 2. Bilateral epiretinal membranes on OCT images. (C) CNTF-treated and sham-treated eyes of patient 3. No AOSLO images were acquired in the sham-treated eye of patient 3 because of severe cystoid macular edema and vitreous opacities (arrow points to opacity obscuring retinal detail).

Katherine E. Talcott, et al. Invest Ophthalmol Vis Sci. 2011 April;52(5):2219-2226.

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