Results: 3

1.
Figure 1.

Figure 1. From: Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release.

Schematic figure of the interaction between RyR and various modulators. Left panel illustrates skeletal muscle and right panel shows cardiac muscle. Modulators bind to the RyR tetramer but are for simplicity only depicted on one monomer.

Johanna T. Lanner, et al. Cold Spring Harb Perspect Biol. 2010 November;2(11):a003996.
2.
Figure 3.

Figure 3. From: Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release.

Cryo-EM reconstruction of RyR1 at 9.6 Å resolution. Cytoplasmic domain (A) and side view (B) of RyR1 with the different subdomains mapped by Irina Serysheva (See section “structural studies” for detailed information).

Johanna T. Lanner, et al. Cold Spring Harb Perspect Biol. 2010 November;2(11):a003996.
3.
Figure 2.

Figure 2. From: Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release.

Linear presentation of RyR primary sequence outlining known mutations associated with skeletal and cardiac muscle diseases. Diamond shaped dots represent RyR1 mutations associated with: MH (151 mutations), CCD (63 mutations), and MmD (blue, 6 mutations) or other myopathies (MP, red, 4 mutations). Circles represent RyR2 mutations associated with: CPVT (53 mutations) and ARVD2 (5 mutations). Data collected from HGMD® (database of human gene mutation data) until 2006, UniProt 2007–2009, and publication by Vukcevic et al. 2010).

Johanna T. Lanner, et al. Cold Spring Harb Perspect Biol. 2010 November;2(11):a003996.

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