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Results: 4

1.
Figure 4

Figure 4. From: Nectin 4 Overexpression in Ovarian Cancer Tissues and Serum.

Nectin 4 enzyme-linked immunosorbent assay analysis. A, Serum nectin 4 levels (ng/mL) separated by diagnosis. B, Receiver operating characteristic (ROC) curves for nectin 4 alone (dash-dot line), CA125 alone (dashed line), or nectin 4 and CA125 combined (solid line). Area under the ROC curve for nectin 4 and CA125, 0.7620; for nectin 4, 0.0863; and for CA125, 0.6569.

Melissa S. DeRycke, et al. Am J Clin Pathol. ;134(5):835-845.
2.
Figure 1

Figure 1. From: Nectin 4 Overexpression in Ovarian Cancer Tissues and Serum.

Nectin 4 gene overexpression in ovarian cancer. A, Reverse transcriptase–polymerase chain reaction (RT-PCR) of nectin 4 in ovarian cancer (C1–C5) and normal ovarian tissue (N1–N7). MCF7 cell line, positive control. −RT, no reverse transcriptase; −RNA, no RNA. B, Quantitative RT-PCR analysis of nectin 4 expression in immortalized NOSE and ovarian cancer cell lines. Results expressed as fold-change compared with the lowest expressing cell line (1816-575). *OVCAR3 messenger RNA was increased 454-fold over the lowest expressing cell line.

Melissa S. DeRycke, et al. Am J Clin Pathol. ;134(5):835-845.
3.
Figure 3

Figure 3. From: Nectin 4 Overexpression in Ovarian Cancer Tissues and Serum.

Immunohistochemical staining for nectin 4 of ovarian cancer tissue microarrays. A, Staining and grading examples of tissue microarray (TMA) samples. IgG, control primary stain. +1, <10% of cancer cells staining; +2, 10%–50% of cancer cells staining; and +3, >50% of cancer cells staining. B, Percentage of TMA cases positive for nectin 4 by ovarian cancer subtype. C, Percentage of TMA cases positive for nectin 4 by Silverberg grade. D, Kaplan-Meier survival curve of TMA patients measured in days. Red, staining score 0; green, staining score +1; blue, staining score +2; orange, staining score +3.

Melissa S. DeRycke, et al. Am J Clin Pathol. ;134(5):835-845.
4.
Figure 2

Figure 2. From: Nectin 4 Overexpression in Ovarian Cancer Tissues and Serum.

Nectin 4 protein expression in ovarian cancer. A, Western immunoblotting of ovarian cancer cell lines and immortalized normal ovarian surface epithelial (NOSE) cell lines. Nectin 4 appears as an approximately 66-kDa band. β-Actin was used as a loading control. B, Flow cytometric analysis of ovarian cancer and immortalized NOSE cell lines for nectin 4 (top row), nectin 1 (middle row), and ADAM17 (bottom row). Nectin 1 expression indicates that trans-heterodimers may form between nectin 4– and nectin 1–expressing cells. Expression of ADAM17 indicates that nectin 4 may be cleaved from the surface of the cells and may be detectable in patient serum samples. Dashed line, IgG control stain; solid line, nectin 4, nectin 1, or ADAM17.

Melissa S. DeRycke, et al. Am J Clin Pathol. ;134(5):835-845.

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