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Results: 3

1.
Figure 2

Figure 2. From: Hierarchical clustering of HPV genotype patterns in the ASCUS-LSIL triage study.

Hierarchical clustering of disease groups by genotype prevalence
Disease combinations based on histology (no biopsy, normal, CIN1, CIN2, CIN3) and cytology (normal, ASCUS, LSIL, HSIL) are shown in the colums, N indicates the number of women in each disease combination. HPV genotypes are shown in rows. The heatmap shows type-specific prevalence determined by LBA in grey-scale for each type-disease stage combination. Darker grey indicates higher prevalence. Dendrograms are shown for both disease groups and HPV genotypes. Four disease clusters are labeled 1–4. Three genotype clusters are labeled 1–3; the subgroups are labeled 2a–c and 3a–b.

Nicolas Wentzensen, et al. Cancer Res. ;70(21):8578-8586.
2.
Figure 1

Figure 1. From: Hierarchical clustering of HPV genotype patterns in the ASCUS-LSIL triage study.

Consort diagram
Flow chart of individuals included in the analysis. Women were referred to ALTS from four clinical centers with a cytology diagnosis of ASCUS (3488 women enrolled) or LSIL (1572 women enrolled). Women were randomized into three trial arms: Immediate Colposcopy, HPV Triage, and Conservative Management. Our analysis included all women who received a colposcopy at the enrollment visit. In the Immediate Colposcopy group, all women received colposcopy. Women in the HPV triage arm underwent colposcopy if they were HPV-positive or received a cytology diagnosis of HSIL at their enrollment visit, and women in the Conservative Management arm underwent colposcopy only if they received an HSIL cytology diagnosis at enrollment. 2780 women were included in our final analysis.

Nicolas Wentzensen, et al. Cancer Res. ;70(21):8578-8586.
3.
Figure 3

Figure 3. From: Hierarchical clustering of HPV genotype patterns in the ASCUS-LSIL triage study.

Disease group dendrogram with 2-year risk of CIN3 and clinical characteristics
The dendrogram from the heatmap in Figure 2 is shown with the corresponding disease combinations based on histology (no biopsy, normal, CIN1, CIN2, CIN3) and cytology (normal, ASCUS, LSIL, HSIL). The columns two year-risk of CIN3, two year-risk of CIN2 or greater, two-year risk of confirmed CIN3 (CIN3 with a consensus clinical center and quality control diagnosis), percent of women over age 25 at enrollment, median age, percent of women smoking at enrollment, percent of women with high grade colposcopy at enrollment, percent women with a clinical center HSIL cytology result, percent women with a positive cervigram, median RLU/PC value in hybrid capture 2, percent women with a positive hybrid capture 2 result. All percentages and median values, respectively, are given for the four disease clusters.

Nicolas Wentzensen, et al. Cancer Res. ;70(21):8578-8586.

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