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Results: 3

1.
Figure 1

Figure 1. From: The Genetics of Parkinson Disease.

SNCA (PARK1/PARK4) gene and protein structure. All exons and functional domains are shown. All 3 point mutations identified to date are also shown. ATG indicates the beginning of the coding region (gray); Ex, exon; aa, amino acid.

Lynn M. Bekris, et al. J Geriatr Psychiatry Neurol. ;23(4):228-242.
2.
Figure 2

Figure 2. From: The Genetics of Parkinson Disease.

LRRK2 (PARK8) gene and protein structure. Established pathogenic mutations (boldface) and risk variants (gray) are shown. Variants specific to Asian populations are indicated by an asterisk. ARM indciates Armadillo region; ANK, Ankyrin repeat region; LRR, leucine-rich repeat domain; ROC, Ras of complex; COR, C terminal of Ras (GTPase);. MAPKKK, mitogen-activated protein kinase kinase kinase; Ex, exon; aa, amino acid.

Lynn M. Bekris, et al. J Geriatr Psychiatry Neurol. ;23(4):228-242.
3.
Figure 3

Figure 3. From: The Genetics of Parkinson Disease.

PARK2 gene and protein structure. More than 100 mutations have been identified. Number of mutations in each exon is shown as reported in the PD mutation database http://grenada.lumc.nl/LOVD2/TPI/home.php?select_db=PARK2. Hot spots for parkin mutations are concentrated in exons 2 and 7, whereas hot spots for exon rearrangements occur in introns 2 through 4. ATG indicates the beginning of the coding region (gray); UBL, ubiquitin-like domain; Ex, exon; aa, amino acid.

Lynn M. Bekris, et al. J Geriatr Psychiatry Neurol. ;23(4):228-242.

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