We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 4

1.
Figure 1

Figure 1. From: Pathological 43-kDa Transactivation Response DNA-Binding Protein in Older Adults With and Without Severe Mental Illness.

Subpial or subependymal 43-kDa transactivation response DNA-binding protein (TDP-43) pathology. Anti–TDP-43 immunohistochemical examination using phosphorylation-independent (B, D, and E) and antiphosphorylated S409/410 (A and C) TDP-43 antibodies. A, Schizophrenia with superimposed dementia with many subpial dystrophic cellular processes in the periamygdaloid cortex (arrow) (bar=500 μm). B, Amygdala of a subject with schizophrenia showing subependymal cytoplasmic granular TDP-43 immunoreactivity (arrow) (bar=100 μm). C, Higher magnification of part A showing dystrophic cellular processes (eg, arrow) (bar=200 μm). D, High magnification of part B showing granular TDP-43 immunoreactivity (eg, arrow) (bar=20 μm). E, Alveus of a subject with schizophrenia with superimposed dementia showing subependymal cytoplasmic TDP-43 immunoreactivity (large arrow) and dystrophic cellular processes (small arrow) (bar=50 μm).

Felix Geser, et al. Arch Neurol. ;67(10):1238-1250.
2.
Figure 3

Figure 3. From: Pathological 43-kDa Transactivation Response DNA-Binding Protein in Older Adults With and Without Severe Mental Illness.

Diffuse 43-kDa transactivation response DNA-binding protein (TDP-43) pathology. Anti–TDP-43 immunohistochemical examination using phosphorylation-independent (A) and antiphosphorylated S409/410 (B–D) TDP-43 antibodies. A, CA1-subiculum area of the hippocampus showing severe dystrophic TDP-43 pathology in a subject with mild cognitive impairment (eg, arrow) (bar=100 μm). B, CA1-subiculum area of the hippocampus showing severe dystrophic TDP-43 pathology in a subject with schizophrenia (eg, arrow) (bar=100 μm). C, Subject with schizophrenia with superimposed dementia with neuronal TDP-43 pathology in the periamygdaloid cortex (bar=100 μm) (eg, arrow). D, Dentate gyrus in the hippocampus of a subject with mild cognitive impairment showing some neuronal cytoplasmic inclusions (eg, arrow). E–J, TDP-43 and tau double immunofluorescence immunohistochemical examination using phosphorylation-independent anti–TDP-43 antibodies (E and H) and paired helical filament-1 antibodies (F and I). E–G, Periamygdaloid cortex of a subject with schizophrenia with superimposed dementia showing variable colocalization of pathological tau (F) and TDP-43 (E) (merge in part G) inclusions (eg, arrow) (bar=100 μm). H–J, Hippocampus of a subject with mild cognitive impairment demonstrating convergence of tau (l) and TDP-43 (H) (merge in part J) pathology in a dystrophic plaque (marked by arrows) (bar=50 μm).

Felix Geser, et al. Arch Neurol. ;67(10):1238-1250.
3.
Figure 2

Figure 2. From: Pathological 43-kDa Transactivation Response DNA-Binding Protein in Older Adults With and Without Severe Mental Illness.

Focal 43-kDa transactivation response DNA-binding protein (TDP-43) pathology. Anti–TDP-43 immunohistochemical examination using phosphorylation-independent (A–F) anti–TDP-43 antibody. A and B, (Trans)entorhinal cortex of a patient with schizophrenia. A, Lack of endogenous TDP-43 staining (“cleared nucleus”) (large arrow) and hardly discernable cytoplasmic TDP-43 immunoreactivity (small arrow) (bar=20 μm) in a neuron. B, Medium-size dense neuronal cytoplasmic inclusions (large arrow) and 2 smaller TDP-43 pathological aggregations (small arrow) (bar=20 μm). C, Large neuronal cytoplasmic inclusion (large arrow) and a cleared nucleus (small arrow) subadjacent to the hippocampal pyramidal cell layer in a subject with schizophrenia (bar=20 μm). D, Skeinlike inclusion in a nigral neuron (large arrow) associated with a cleared nucleus in a patient with schizophrenia (small arrow) (bar=20 μm). E, Neuronal intranuclear inclusion (large arrow) in a cell devoid of the endogenous nuclear staining in the hippocampal CA1 area neuron in an elderly control with mild cognitive impairment (bar=20 μm). Note the presence of normal nuclear staining in surrounding neurons (small arrow).

Felix Geser, et al. Arch Neurol. ;67(10):1238-1250.
4.
Figure 4

Figure 4. From: Pathological 43-kDa Transactivation Response DNA-Binding Protein in Older Adults With and Without Severe Mental Illness.

Perivascular 43-kDa transactivation response DNA-binding protein (TDP-43) pathology. Anti–TDP-43 immunohistochemical examination using phosphorylation-independent (F and G) and antiphosphorylated S409/410 (A–E and H) TDP-43 antibodies in the amygdala or periamygdaloid areas. A and B, Low-power magnification of a severe perivascular lesion showing predominantly dystrophic TDP-43 immunoreactive cellular profiles in the periamygdaloid white matter (A) (eg, arrow) or TDP-43 immunoreactivity in the cytoplasm and proximal cellular processes in the amygdala (B) in 2 elderly control subjects (bars=500 μm). C, Same control subject as in part A showing perivascular, mainly dystrophic (eg, arrow), TDP-43 immunoreactivity at a higher magnification (bar=200 μm). D, Subject with schizophrenia with superimposed dementia with perivascular dystrophic TDP-43 pathology in the periamygdaloid white matter (eg, arrow) (bar=200 μm). E and F, Medium-power (E) (bar=200 μm) and high-power (F) (bar=50 μm) views of the same control subject as shown in part B. Note the presence of predominantly cytoplasmic TDP-43 immunoreactivity (eg, arrows), coupled with a lack of endogenous nuclear TDP-43 staining in part F. G and H, Capillary-associated TDP-43 pathology in periamygdaloid gray matter in a patient with schizophrenia and superimposed dementia (arrows) (bars=20 μm).

Felix Geser, et al. Arch Neurol. ;67(10):1238-1250.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk