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Results: 12

1.
Figure 8

Figure 8. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Voxel based significance maps of the MSD change with age. Image orientation is in radiologic convention. Notations: Red-yellow colorbar: positive correlation with age; color scale: T score; z: MNI space z coordinate in mm.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
2.
Figure 9

Figure 9. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Voxel based significance maps of the f1 change with age. Image orientation is in radiologic convention. Notations: Blue-Lightblue colorbar: negative correlation with age; color scale: T score; z: MNI space z coordinate in mm.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
3.
Figure 7

Figure 7. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Voxel based significance maps of the Po change with age. Image orientation is in radiologic convention. Notations: Red-yellow colorbar: positive correlation with age; color scale: T score; z: MNI space z coordinate in mm.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
4.
Figure 11

Figure 11. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Voxel based significance maps of the Da change with age. Image orientation is in radiologic convention. Notations: Blue-Lightblue colorbar: negative correlation with age; color scale: T score; z: MNI space z coordinate in mm.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
5.
Figure 10

Figure 10. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Voxel based significance maps of the FA change with age. Image orientation is in radiologic convention. Notations: Blue-Lightblue colorbar: negative correlation with age; color scale: T score; z: MNI space z coordinate in mm.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
6.
Figure 12

Figure 12. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Voxel based significance maps of the changes of MSD (a)–(e), f1 (f), D2 (g), FA (h), MD (i) and Dr (j) with gender (female: 0 and male: 1). Image orientation is in radiologic convention. Notations: Red-Yellow: positive correlation with gender (high in male and low in female); Blue-Lightblue colorbar: negative correlation with gender (low in male and high in female); color scale: T score; z: MNI space z coordinate in mm.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
7.
Figure 1

Figure 1. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Example white matter mask and ROIs. (a) White matter (WM) probability mask with color scales denoting classification probability. (b) Tissue segmentation on Po map. White: WM, Gray: gray matter (GM) and dark gray: cerebrospinal fluid (CSF). Red: ROIs, from anterior to posterior: genu of the corpus callosum (CCg), posterior limbs of bilateral internal capsules (PLIC) and splenium of the corpus callosum (CCs). ROIs are all three-dimensional and cover four consecutive slices. The original Po map of the same subject is in Figure 2 (a).

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
8.
Figure 5

Figure 5. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Results of linear regression of diffusion measures versus age for ROI at the posterior limbs of the internal capsule (PLIC). PDF measures (a) Po; (b) MSD. Bi-exponential model fitting of the whole dataset: (c) f1; (d) D1; (e) D2. DTI measures from inner shell: (f) FA; (g) MD; (h) Da; (i) Dr. Gender effect if significant has been corrected from these plots. Fitted equations are shown on top of each panel, where the linear model was DW measure = constant + β1*age + error, p, i.e. p-value, denotes the significance of fit and R denotes the correlation coefficient. Cross (+) and circle (○) denotes averaged diffusion measurements at that age for male and female respectively. A.U. denotes arbitrary unit.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
9.
Figure 2

Figure 2. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Maps of diffusion-weighted (DW) measures of a 26 year old male subject in HYDI experiment. From the whole dataset, PDF measures: (a) Po, zero displacement probability, a measure of tissue restriction; (b) MSD, mean squared displacement, a measure of averaged diffusivity. Bi-exponential model fitting of the whole dataset: (c) f1, the volume fraction of the fast diffusion compartment; (d) f2, the volume fraction of the slow diffusion compartment; (e) D1, averaged diffusivity of the fast compartment; (f) D2, averaged diffusivity of the slow compartment. DTI measures from inner shell: (g) FA, fractional anisotropy of diffusion tensor (DT) model; (h) MD, mean diffusivity of DT model; (i) Da, axial diffusivity, (j) Dr, radial diffusivity, and (k) major eigenvector colormap.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
10.
Figure 4

Figure 4. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Results of linear regression of diffusion measures versus age for ROI at the genu of corpus callosum (CCg). PDF measures (a) Po; (b) MSD. Bi-exponential model fitting of the whole dataset: (c) f1; (d) D1; (e) D2. DTI measures from inner shell: (f) FA; (g) MD; (h) Da; (i) Dr. Gender effect if significant has been corrected from these plots. Regression lines were plotted only for measures with significant fit, i.e. p < 0.05. Fitted equations are shown on top of each panel, where the linear model was DW measure = constant + β1*age + error, p, i.e. p-value, denotes the significance of fit and R denotes the correlation coefficient. Cross (+) and circle (○) denotes averaged diffusion measurements at that age for male and female respectively. A.U. denotes arbitrary unit.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
11.
Figure 6

Figure 6. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Results of linear regression of diffusion measures versus age for ROI at the splenium of corpus callosum (CCs). PDF measures (a) Po; (b) MSD. Bi-exponential model fitting of the whole dataset: (c) f1; (d) D1; (e) D2. DTI measures from inner shell: (f) FA; (g) MD; (h) Da; (i) Dr. Gender effect if significant has been corrected from these plots. Regression lines were plotted only for measures with significant fit, i.e. p < 0.05. Fitted equations are shown on top of each panel, where the linear model was DW measure = constant + β1*age + error, p, i.e. p-value, denotes the significance of fit and R denotes the correlation coefficient. Cross (+) and circle (○) denotes averaged diffusion measurements at that age for male and female respectively. A.U. denotes arbitrary unit.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.
12.
Figure 3

Figure 3. From: Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI).

Results of linear regression of diffusion measures versus age for whole-brain white matter. PDF measures: (a) Po, zero displacement probability; (b) MSD, mean squared displacement, a measure of averaged diffusivity using Einstein diffusion equation. Bi-exponential model fitting of the whole dataset: (c) f1, the volume fraction of the fast diffusion compartment; (d) D1, averaged diffusivity of the fast compartment; (e) D2, averaged diffusivity of the slow compartment. DTI measures from inner shell: (f) FA, fractional anisotropy; (g) MD, mean diffusivity; (h) Da, axial diffusivity, (i) Dr, radial diffusivity. Gender effect if significant has been corrected from these plots. Regression lines were plotted only for measures with significant fit, i.e. p < 0.05. Fitted equations are shown on top of each panel, where the linear model was DW measure = constant + β1*age + error, p, i.e. p-value, denotes the significance of fit and R denotes the correlation coefficient. Cross (+) and circle (○) denotes averaged diffusion measurements at that age for male and female respectively. A.U. denotes arbitrary unit.

Yu-Chien Wu, et al. Neuroimage. ;54(3):1840-1853.

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