Results: 4

1.
Figure 1

Figure 1. From: Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias.

Representative images of acinar-to-ductal metaplasia. a-d) Isolated acinar-to-ductal metaplasia. Metaplastic acinar-to-ductal metaplasia cells make luminal structures. Some metaplastic cells contain eosinophilic cytoplasmic granules which are characteristic of acinar cells. E-h) PanIN-associated acinar-to-ductal metaplasias. Metaplastic cells contain supranuclear mucin, others have eosinophilic cytoplasmic granules. g) Higher magnification of h. h) Shows spectrum from normal acini, isolated acinar-to-ductal metaplasias, PanIN-associated acinar-to-ductal metaplasias, and PanIN (arrows).

Seung-Mo Hong, et al. Mod Pathol. ;24(2):256-266.
2.
Figure 4

Figure 4. From: Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias.

The normalized mean telomere fluorescence of metaplastic and precursor lesions of the pancreas based on underlying patient diagnosis. Each dot represents the normalized mean telomere fluorescence of cells from patients with cancers. Each x-mark represents the normalized mean acinar-to-ductal metaplasia telomere fluorescence of cells from patients without cancer. Telomere lengths were not significantly different in isolated acinar-to-ductal metaplasia lesions, PanIN-associated acinar-to-ductal metaplasias, and PanINs by underlying patient diagnosis.

Seung-Mo Hong, et al. Mod Pathol. ;24(2):256-266.
3.
Figure 3

Figure 3. From: Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias.

The normalized mean telomere fluorescence of normal, metaplastic and neoplastic lesions of the pancreas; Telomeres are significantly shorter in PanIN-associated acinar-to-ductal metaplasias (p<0.05, post hoc Duncan test) and in PanINs (p<0.05), than they are in acinar cells, ductal cells, fibroblasts, or isolated acinar-to-ductal metaplasia. However there was no significant difference of the telomere lengths among other cell types.

Seung-Mo Hong, et al. Mod Pathol. ;24(2):256-266.
4.
Figure 2

Figure 2. From: Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias.

Representative images of telomere FISH. Nuclei are stained with DAPI (blue). The telomeres are stained with a Cy3-labeled telomere specific FISH probe (small red dots in nuclei) and the centromeres are stained with FITC-labeled centromere specific FISH probes (small green dots in nuclei). Telomeric signals in isolated acinar-to-ductal metaplasias (asterisks) are retained and are similar to those in acinar (AC) and ductal cells. However, telomeric signals in PanIN-associated acinar-to-ductal metaplasias (arrowheads) and in PanIN (arrows) are weaker than those in acinar (AC) and ductal cells. a) Ductal cells. B-d) Isolated acinar-to-ductal metaplasias (asterisks) and acinar cells (AC). E-g) PanIN-associated acinar-to-ductal metaplasias (arrowheads) and acinar cells (AC). h) PanIN (arrows) and acinar cells (AC).

Seung-Mo Hong, et al. Mod Pathol. ;24(2):256-266.

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