Results: 2

1.
Figure 1

Figure 1. From: A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.

Forest plots of the associations by country of residence of BRCA1 mutation carriers in the combined stage 1 and stage 2 samples. (a,b) Squares indicate the country specific per-allele HR estimates for SNPs rs8170, rs4808611 (a) and rs8100241, rs2363956 (b). The area of the square is proportional to the inverse of the variance of the estimate. Horizontal lines indicate 95% CIs.

Antonis C Antoniou, et al. Nat Genet. ;42(10):885-892.
2.
Figure 2

Figure 2. From: A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.

Above, results of the kinship-adjusted score test statistic (1 d.f.) by position (kb) in stage 1 and 2 samples combined for genotyped and imputed SNPs in the associated region (chromosome 19, positions 17,100–17,400 kb). Genotyped SNPs in stages 1 or 2 are shown in red and imputed SNPs are shown in black. The horizontal dotted line indicates the P values for the strongest association among genotyped SNPs (rs8170). At middle, the linkage disequilibrium (LD) blocks around the top five associated SNPs (chromosome 19, positions 17,150–17,350 kb) in the combined analysis of stage 1 and stage 2 samples based on the 1000 Genomes Project data for the samples of European ancestry. Squares in the LD blocks indicate pairwise correlations between the SNPs (r2) by grayscale (darker symbols indicate correlations closer to 1). Below, details of the region containing the most significantly associated genotyped and imputed SNPs (chromosome 19, positions 17,210–17,268 kb). Location of genotyped SNPs shown by numbers 1–5 and the eight most significantly associated imputed SNPs are shown in letters A–H (P = 9.0 × 10−12 to P = 1.0 × 10−11).

Antonis C Antoniou, et al. Nat Genet. ;42(10):885-892.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk