Results: 5

1.
Figure 2

Figure 2. Comparison of PDTP and PDRP spatial topographies. From: Parkinson's Disease Tremor-Related Metabolic Network: Characterization, Progression, and Treatment Effects.

Display of brain areas contributing to the PDTP (red) and PDRP (green) metabolic networks. Areas of overlap between the two patterns (yellow) were evident in the cerebellum, pons, and putamen. For each pattern, the voxel displays were thresholded at Z=2.70, p<0.01 and superimposed on a standard magnetic resonance imaging template.

Hideo Mure, et al. Neuroimage. ;54(2):1244-1253.
2.
Figure 3

Figure 3. Validation of PDTP expression as a network correlate of parkinsonian tremor. From: Parkinson's Disease Tremor-Related Metabolic Network: Characterization, Progression, and Treatment Effects.

A. Bar graph showing mean PDTP (±SE) in a prospective group of 41 PD patients (black bars) and 20 age-matched healthy control subjects (white bars). The expression of this disease-related pattern was elevated in this testing group (p<0.001, relative to controls).
B. PDTP expression correlated (r=0.54, p<0.001) with UPDRS subscale ratings for tremor in the PD group.
C. The correlation of PDTP scores with tremor was significantly greater in magnitude (p<0.01; multiple regression analysis) than with subscale ratings for akinesia-rigidity (see text).
D. Bar graph showing mean PDTP subject scores (±SE) in tremor dominant and akinesia-rigidity dominant PD patients (arPD and tPD, respectively), and in normal control (NC) subjects undergoing perfusion imaging with ECD SPECT (see text). PDTP expression was significantly higher in the tPD patients than in the arPD (p<0.05) and NC groups (p=0.001).

Hideo Mure, et al. Neuroimage. ;54(2):1244-1253.
3.
Figure 5

Figure 5. Changes in metabolic network activity with deep brain stimulation for PD tremor. From: Parkinson's Disease Tremor-Related Metabolic Network: Characterization, Progression, and Treatment Effects.

A. Bar graphs showing mean baseline PDTP expression (±SE) in the Vim DBS patients (black), the STN DBS patients (gray), and the healthy control subjects (white). There was a significant difference in PDTP expression across the three groups (p<0.001; one-way ANOVA), with comparable elevations in baseline pattern expression in both the Vim DBS (p<0.005) and STN DBS groups (p<0.001) relative to controls.
B. Baseline PDRP expression also differed across the three groups (p<0.001), with higher expression in both treatment groups relative to controls (p<0.001). Nonetheless, PDRP expression was higher in the STN than in the Vim DBS group (p<0.01).
C. Treatment-mediated changes (ON–OFF) in mean PDTP expression (±SE) in the Vim DBS patients (black), the STN DBS patients (gray), and the test-retest PD control subjects (white). Changes in PDTP expression were different across the three groups (p<0.001; one-way ANOVA), with stimulation-mediated declines in network activity in both DBS groups (Vim: p<0.001; STN: p=0.01, relative to the test-retest control group). PDTP modulation was greater with Vim than STN stimulation (p<0.05).
D. There was also a significant group difference in treatment-mediated PDRP modulation (p=0.02). Treatment-mediated reductions in PDRP expression reached significance (p<0.05) with STN stimulation, but not with Vim stimulation (p=0.16).

Hideo Mure, et al. Neuroimage. ;54(2):1244-1253.
4.
Figure 1

Figure 1. Parkinson’s disease tremor-related pattern (PDTP). From: Parkinson's Disease Tremor-Related Metabolic Network: Characterization, Progression, and Treatment Effects.

A. Spatial covariance pattern identified by ordinal trends canonical variate analysis (OrT/CVA) of FDG PET data from nine tremor dominant PD patients scanned on and off Vim stimulation (see text). The pattern was characterized by increased metabolic activity in the primary motor cortex, anterior cerebellum/dorsal pons, and the caudate/putamen. [The covariance map was overlaid on T1-weighted MR-template images. Voxel weights were thresholded at Z=2.70, p<0.01. The display represents regions that were demonstrated to be reliable (p<0.05) by bootstrap resampling].
B. The expression of this PD tremor-related metabolic pattern (PDTP) was reduced by Vim stimulation in 10 of the 11 treated hemispheres (p<0.005, permutation test).
C. Baseline PDTP expression (i.e., off-stimulation pattern scores) correlated (r=0.85, p<0.02) with concurrent accelerometric measurements of tremor amplitude (see text).

Hideo Mure, et al. Neuroimage. ;54(2):1244-1253.
5.
Figure 4

Figure 4. Changes in PDTP expression with disease progression. From: Parkinson's Disease Tremor-Related Metabolic Network: Characterization, Progression, and Treatment Effects.

A. Mean (±SE) off-state total motor UPDRS ratings (diamonds), and akinesia-rigidity (triangles) and tremor subscale ratings (squares), from a longitudinal cohort of early stage PD patients (n=15) followed at baseline, 24, and 48 months (Huang et al., 2007b). These ratings worsened over time (total motor UPDRS, p<0.0001; akinesia-rigidity: p<0.05; tremor: p=0.01; one-way RMANOVA), but at different progression rates (see text). Relative to baseline, significant increaes in the akinesia-rigidity and tremor ratings (p<0.05; post-hoc Bonferroni test) were evident only at the 48 month time point. *p<0.05, ***p<0.0001, post-hoc Bonferroni test relative to baseline.
B. Mean (±SE) PDTP (squares) and PDRP (diamonds) scores at baseline, 24 and 48 months. The expression of both patterns increases significantly over time (PDTP: p=0.01; PDRP: p<0.0001; one-way RMANOVA). The time course of network activity differed for the two patterns (p<0.01), with a slower rate of progression for PDTP (0.10 point/year, p<0.05) relative to PDRP (0.51 point/year, p<0.0001). Relative to baseline, there was no change in PDTP expression at 24 months (p=0.99; post-hoc Bonferroni test), although a significant increase was evident at 48 months (p<0.05). However, significant increases in PDRP expression were evident at both the second (p<0.05) and third time points (p<0.0001). *p<0.05, ***p<0.001, post-hoc Bonferroni tests with respect to baseline.

Hideo Mure, et al. Neuroimage. ;54(2):1244-1253.

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