Figure 1

Figure 1. Gadolinium-Enhanced Cardiac MRI Scans in MYH7 Mutation Carriers with and Those without Overt Hypertrophic Cardiomyopathy. From: Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy.

Panels A, C, and E show no morphologic abnormalities suggestive of hypertrophic cardiomyopathy in a carrier of a myosin heavy-chain missense mutation. Left ventricular hypertrophy and late gadolinium enhancement are absent. Panels B, D, and F show typical findings of hypertrophic cardiomyopathy in a relative of the subject in Panels A, C, and E with overt disease caused by the same myosin heavy-chain mutation. These findings include a markedly thickened septum (Panel B, arrow) associated with areas of heterogeneous late gadolinium enhancement, which affects 17% of the total left ventricular mass and involves the anteroseptum (Panel D, arrows) and the inferoseptum (Panels D and F, arrows). LA denotes left atrium, LV left ventricle, RA right atrium, and RV right ventricle.

Carolyn Y. Ho, et al. N Engl J Med. ;363(6):552-563.

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