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1.
Figure 4

Figure 4. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Chemical formulae of telomestatin-related macrocycles.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
2.
Figure 7

Figure 7. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Chemical formulae of porphyrin-based G-quadruplex ligands.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
3.
Figure 11

Figure 11. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Chemical formulae of Hemin (a) and NMM (b).

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
4.
Figure 2

Figure 2. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Chemical structures of telomestatin and TMPyP4 (with p-CH3(C6H4)SO3 as counterions).

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
5.
Figure 9

Figure 9. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Chemical structures of corrole-, porphyrazine-, phthalocyanine-, and sapphyrin-based G-quadruplex ligands.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
6.
Figure 13

Figure 13. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Chemical formulae of nonplanar macrocyclic G-quadruplex ligands: BOQ1 (a), BisA (b), and the neomycin-capped scaffold NCQ (c).

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
7.
Figure 8

Figure 8. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Polyheterocyclic macrocyclic cores used in the structures of G-quadruplex ligands. The number in the center corresponds to the number of atoms in the central ring.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
8.
Figure 6

Figure 6. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Interaction of TMPyP4 and a G-tetrad (adapted from PDB entry: 2A5R); guanine residues appear in gold; the carbon, nitrogen, oxygen, and hydrogen atoms of TMPyP4 appear in grey, blue, red, and white, respectively.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
9.
Figure 12

Figure 12. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Qualitative in silico superposition of NMM and a G-tetrad (extracted from PDB entry: 2A5R); guanine residues appear in gold; the carbon, nitrogen, oxygen, and hydrogen atoms of NMM in grey, blue, red, and white, respectively.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
10.
Figure 3

Figure 3. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Qualitative in silico superposition of telomestatin and a G-tetrad (extracted from PDB entry: 2A5R); guanine residues appear in gold; the carbon, nitrogen, oxygen, sulphur, and hydrogen atoms of telomestatin appear in grey, blue, red, yellow, and white, respectively.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
11.
Figure 5

Figure 5. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Qualitative in silico superposition of HXDV and a G-tetrad (extracted from PDB entry: 2A5R); guanine residues appear in gold, the carbon, nitrogen, oxygen, and hydrogen atoms of HXDV in grey, blue, red and white, respectively.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
12.
Figure 10

Figure 10. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Qualitative in silico superposition of 3,4-TMPyPz (a) and corrole (b) and a G-tetrad (extracted from PDB entry: 2A5R); guanine residues appear in gold; the carbon, nitrogen, oxygen, and hydrogen atoms of the ligands in grey, blue, red, and white, respectively.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
13.
Figure 1

Figure 1. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Schematic representation of the folding of an oligonucleotide that mimics the human telomeric sequence (d[AG3(T2AG3)3]). The polymorphism of the quadruplex is represented through the various possible structures, namely, the hybrid (left), antiparallel (centre), and parallel (right) forms; these structures differ by strand orientation (grey dashed arrows) and loop arrangement (represented in orange, yellow, and red).

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.
14.
Figure 14

Figure 14. From: "One Ring to Bind Them All"--Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition.

Structure of BOQ1 (a), side (b), and front views (c) of the lowest-energy conformation during the molecular dynamic simulation (see [39]) and modelled interaction between BOQ1 and the human telomeric quadruplex ((d), see [205]); guanine residues appear in gold; the carbon, nitrogen, oxygen, and hydrogen atoms appear in grey, blue, red, and white, respectively.

David Monchaud, et al. J Nucleic Acids. 2010;2010:525862.

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