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1.
Fig. 5.

Fig. 5. From: Defining a rat blood pressure quantitative trait locus to a <81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis.

The list of upregulated genes in the congenic strain compared with S given in Table 2 were modeled using Ingenuity Pathway Analysis. Upregulated genes are shown in shades of red based on the fold-change in expression.

K. Gopalakrishnan, et al. Physiol Genomics. 2010 October;42A(2):153-161.
2.
Fig. 6.

Fig. 6. From: Defining a rat blood pressure quantitative trait locus to a <81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis.

The list of downregulated genes in the congenic strain compared with S given in Table 2 were modeled using Ingenuity Pathway Analysis. Downregulated genes are shown in shades of green based on the fold-change in expression.

K. Gopalakrishnan, et al. Physiol Genomics. 2010 October;42A(2):153-161.
3.
Fig. 3.

Fig. 3. From: Defining a rat blood pressure quantitative trait locus to a <81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis.

Kaplan-Meier plot. Animals were fed with 2% dietary salt (NaCl) and allowed to live until their natural death. Survival analysis was performed using the Graph pad Prism software (http://www.graphpad.com/prism/Prism.htm). Survival of S is significantly different from that of the congenic strain [log-rank (Mantel-Cox) test, P = 0.0004].

K. Gopalakrishnan, et al. Physiol Genomics. 2010 October;42A(2):153-161.
4.
Fig. 4.

Fig. 4. From: Defining a rat blood pressure quantitative trait locus to a <81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis.

Comprehensive representation of BP QTL mapping on RNO9. Logarithm of the odds (LOD) plot for BP using the F2 (S × R) population is shown at the top followed by the congenic strains constructed to map the QTL. All iterations of substitution mapping are shown by congenic strains with 1) BP lowering effect of the S rat BP shown in green, 2) BP increasing effect of the S rat BP shown in black, and 3) the ones without the BP lowering effect shown in gray. Markers shown flank the congenic segment and are of the S genotype.

K. Gopalakrishnan, et al. Physiol Genomics. 2010 October;42A(2):153-161.
5.
Fig. 2.

Fig. 2. From: Defining a rat blood pressure quantitative trait locus to a <81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis.

BP effect of the quantitative trait locus (QTL) region detected by radiotelemetry. We surgically implanted 10 S (♦) and 11 S.R(D9Mco95-D9Mco98) congenic (◊) rats with C40 telemetry transmitters, allowed to them to recover for 4 days, and recorded BP over a period of 4 days. The data plotted were obtained by telemetry recording once every 5 min continuously and averaged for 4 h intervals. Data for all parameters were significantly different between S and congenic rats (T test, P < 0.001).

K. Gopalakrishnan, et al. Physiol Genomics. 2010 October;42A(2):153-161.
6.
Fig. 1.

Fig. 1. From: Defining a rat blood pressure quantitative trait locus to a <81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis.

Substitution mapping of rat chromosome 9 (RNO9). Polymorphic microsatellite markers along with their locations on the rat genome according to the Ensembl database (http://www.ensembl.org, Nov. 2009) are shown to the left. Congenic strains are represented as colored bars: green, strains that lowered blood pressure (BP) of the S rat; black, strains that increased the BP of the S rat; and grey, strains that did not show a change in BP compared with the S. White boxes flanking the colored bars are regions of recombination. The BP effect of each strain is given at the bottom except for S.R(D9Mco95-Resp18), the data for which have been previously published. Details of the effects are given in Table 1. S, Dahl salt sensitive; R. Dahl salt resistant; S.R, congenic strains.

K. Gopalakrishnan, et al. Physiol Genomics. 2010 October;42A(2):153-161.

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