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Results: 5

1.
Figure 1

Figure 1. From: Sulfanegen Sodium Treatment in a Rabbit Model of Sub-Lethal Cyanide Toxicity.

Structure of sulfanegen sodium and enzymatic transfer of sulfur from sulfanegen sodium by 3-mercaptopurine sulfur transferase to pyruvate with conversion of cyanide to thioscyanate (Westley et al., 1983).

Matthew Brenner, et al. Toxicol Appl Pharmacol. ;248(3):269-276.
2.
Figure 2

Figure 2. From: Sulfanegen Sodium Treatment in a Rabbit Model of Sub-Lethal Cyanide Toxicity.

(a) Percent changes of deoxyhemoglobin during CN infusion and post sulfanegen sodium treatment from the representative animals and (b) the averaged fractional changes during sulfanegen sodium or saline administration.

Matthew Brenner, et al. Toxicol Appl Pharmacol. ;248(3):269-276.
3.
Figure 5

Figure 5. From: Sulfanegen Sodium Treatment in a Rabbit Model of Sub-Lethal Cyanide Toxicity.

Correlation between OHb or RHb slope during first 10min post sulfanegen sodium administration and sulfanegen sodium dose. Top two figures (and b) are from sulfanegen sodium IV administration and bottom two figures (c and d) are from sulfanegen sodium IM administration.

Matthew Brenner, et al. Toxicol Appl Pharmacol. ;248(3):269-276.
4.
Figure 3

Figure 3. From: Sulfanegen Sodium Treatment in a Rabbit Model of Sub-Lethal Cyanide Toxicity.

Normalized changes of (a) oxyhemoglobin (OHb) and (b) deoxyhemoglobin (RHb) during cyanide infusion and saline/sulfanegen sodium treatment measured by CWNIRS. Both OHb and RHb from all sulfanegen sodium treated groups showed a faster recovery compared to control group. There was no significant difference of recovery rate between 0.05 mmol IV group and 0.21 mmol IM group.

Matthew Brenner, et al. Toxicol Appl Pharmacol. ;248(3):269-276.
5.
Figure 4

Figure 4. From: Sulfanegen Sodium Treatment in a Rabbit Model of Sub-Lethal Cyanide Toxicity.

Figure 4 shows cyanide levels in red blood cell (RBC) post administration of sulfanegen sodium or saline. For clarity, the error bars up to 20min post sulfanegen sodium administration are not shown. All groups that were treated with sulfanegen sodium showed significantly faster reduction of RBC cyanide level compared to the control. sulfanegen sodium 0.05mmol IM group showed a faster recovery from cyanide poisoning than the control, but was slower in recovery compared to 0.05mmol IV and 0.21mmol IM groups.

Matthew Brenner, et al. Toxicol Appl Pharmacol. ;248(3):269-276.

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