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Results: 4

1.
Fig. 2.

Fig. 2. From: Interaction of JMJD6 with single-stranded RNA.

The similarity and difference of JMJD6 among the cupin fold family members. (A) The cupin fold of JMJD6 is compared to those of Jmjd2a, FIH, and AlkB. JMJD6 is colored magenta, Jmjd2a is colored blue, FIH is colored cyan, and AlkB is colored green. (B) The comparison of JMJD6 on the catalytic core of Jmjd2a. JMJD6 is colored magenta, and Jmjd2a is colored blue.

Xia Hong, et al. Proc Natl Acad Sci U S A. 2010 August 17;107(33):14568-14572.
2.
Fig. 3.

Fig. 3. From: Interaction of JMJD6 with single-stranded RNA.

Unique structural features around the active center of JMJD6. (A) The active center without binding of alpha-KG. Three aromatic residues Tyr131, Phe133, and Trp174 are aligned but not stacking on each other. (B) The overlay of the active center of JMJD6 with and without alpha-KG. In the presence of alpha-KG, the side chain of PHe133 stacks with those of Tyr131 and Trp174. This may represent a mode of substrate recognition.

Xia Hong, et al. Proc Natl Acad Sci U S A. 2010 August 17;107(33):14568-14572.
3.
Fig. 1.

Fig. 1. From: Interaction of JMJD6 with single-stranded RNA.

The overall structure of JMJD6, a new structure of JMJC family. (A) The stereo view of the structure of JMJD6 at present of alpha-KG and Fe2+. The secondary structures are colored as follows: alpha-Helix, red; beta-sheet, yellow; coil, green. (B) The electrostatic surface potentials of JMJD6, positive charged surface is colored red, negative charged surface is colored blue, and neutral surface is colored gray.

Xia Hong, et al. Proc Natl Acad Sci U S A. 2010 August 17;107(33):14568-14572.
4.
Fig. 4.

Fig. 4. From: Interaction of JMJD6 with single-stranded RNA.

JMJD6 binds ssRNA. (A) Binding of full-length JMJD6 to ssRNA. Increasing concentrations of JMJD6 were incubated with a constant amount of 27-nt ssRNA probe prior to fractionation in an EMSA. (B) Progressively shorter ssRNA probes were incubated with (+) or without (−) full-length JMJD6 prior to fractionation in an EMSA. (C) Binding of truncated JMJD6 proteins to the 27-nt ssRNA probe. 1. JMJD6 (1–403), 2. JMJD6 (1–337), 3. JMJD6 (290–403) and 4. JMJD6 (334–403). All protein concentrations are about 200 nM. (D) The potential model of JMJD6 binding to ssRNA.

Xia Hong, et al. Proc Natl Acad Sci U S A. 2010 August 17;107(33):14568-14572.

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