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Results: 3

1.
Figure 3

Figure 3. From: Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset.

MNTB neurons fire patterned action potential bursts during the prehearing period. (a) In vivo extracellular recording from a P5 MNTB neuron. (b) Detail of dashed red box in a. (c) Detail of the mini-burst highlighted in b. Arrowheads indicate pre-spikes. (d) Log-binned ISI histograms for the cell in a. (e) Mean duration (± s.e.m.) of mini-burst intervals within bursts (n = 216 bursts in 19 units). * P < 0.003, paired t-test.

Nicolas X. Tritsch, et al. Nat Neurosci. ;13(9):1050-1052.
2.
Figure 1

Figure 1. From: Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset.

SGNs fire patterned action potential bursts during the prehearing period. (a) In vitro extracellular recording from a SGN at room temperature. (b) Detail of dashed red box in a. (c) Detail of mini-bursts highlighted in b. (d) Overlaid log-binned ISI histograms for the neuron in a (black) and a representative cell at near-physiological temperature (32–35 °C, gray). (e) Mean duration (± s.e.m.) of intervals separating mini-bursts as a function of their relative position within a burst, for recordings performed at 22–24 °C (n = 302 bursts in 23 cochleae) and 32–35 °C (n = 191 bursts in 8 cochleae). Inset: Example of relative mini-burst interval position at the beginning (1 and 5) and end (−1 and −5) of a spontaneous burst. Scale: 0.5 mV, 0.4 s. * P < 0.001, paired t-test. All experimental procedures used in this study were approved by the Animal Care and Use Committees at Johns Hopkins University and Erasmus MC.

Nicolas X. Tritsch, et al. Nat Neurosci. ;13(9):1050-1052.
3.
Figure 2

Figure 2. From: Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset.

IHC Ca2+ spikes initiate action potential mini-bursts in SGNs before hearing onset. (a) Spontaneous burst of Ca2+ spikes recorded from an IHC (22–24 °C). (b) Log-binned histogram of intervals separating Ca2+ spikes within spontaneous bursts (n = 7 IHCs). (c) Mean duration (± s.e.m.) of intervals separating Ca2+ spikes vs. relative position within a burst. * P < 0.05. (d–g) Simultaneous recording from an IHC (whole-cell; gray) and a synaptically-connected SGN (extracellular; black). (d) Continuous paired recording upon 5 consecutive depolarizing current injections of increasing amplitude (20–40 pA). Small hyperpolarizing current steps (−10 pA) were injected every 20 s. Scale bars: 50 mV (top trace), 2 mV (bottom trace); 10 s. (e) IHC membrane potential (Vrest = −80 mV) upon 40 pA injection and corresponding postsynaptic SGN firing. (f) Detail of dashed red box in e. (g) Plot of consecutive intervals (log scale) separating IHC Ca2+ spikes and SGN action potentials from the recording in d. (h) Superimposed log-binned ISI histograms for all IHC Ca2+ spikes and SGN action potentials pooled from 11 paired recordings. Long intervals separating current injections were excluded for clarity.

Nicolas X. Tritsch, et al. Nat Neurosci. ;13(9):1050-1052.

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