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Results: 5

1.
Figure 2

Figure 2. From: In Utero Exposure to Bisphenol A Shifts the Window of Susceptibility for Mammary Carcinogenesis in the Rat.

Western blot analysis of SRC-1, SRC-2, and SRC-3 in mammary glands of (A) 50-day-old and (B) 100-day-old rats exposed prenatally to 250 μg BPA/kg BW or an equal volume of sesame oil (controls). Values represent mean density ± SE as a percentage of the control, with densitometry values for controls set to 100; n = 6–8 samples per group. Insets are representative immunoblots for each protein per treatment.
*p < 0.05 compared with corresponding controls.

Angela M. Betancourt, et al. Environ Health Perspect. 2010 November;118(11):1614-1619.
2.
Figure 1

Figure 1. From: In Utero Exposure to Bisphenol A Shifts the Window of Susceptibility for Mammary Carcinogenesis in the Rat.

Western blot analysis of ER-α, PR-A, and Bcl-2 in mammary glands of (A) 50-day-old and (B) 100-day-old rats exposed prenatally to 250 μg BPA/kg BW or an equal volume of sesame oil (controls). Values represent mean density ± SE as a percentage of the control, with densitometry values for controls set to 100; n = 6–8 samples per group. Insets are representative immunoblots for each protein per treatment.
*p < 0.05 compared with corresponding controls.

Angela M. Betancourt, et al. Environ Health Perspect. 2010 November;118(11):1614-1619.
3.
Figure 3

Figure 3. From: In Utero Exposure to Bisphenol A Shifts the Window of Susceptibility for Mammary Carcinogenesis in the Rat.

Western blot analysis of EGFR, phospho-IGF-1R, phospho-c-Raf, phospho-ERK 1/2, phospho-ErbB2, and phospho-Akt in mammary glands of (A) 50-day-old and (B) 100-day-old rats exposed prenatally to 250 μg BPA/kg BW or an equal volume of sesame oil (controls). Values represent mean density ± SE as a percentage of the control, with densitometry values for controls set to 100; n = 6–8 samples per group. Insets are representative immunoblots for each protein per treatment.
*p < 0.05 compared with corresponding controls.

Angela M. Betancourt, et al. Environ Health Perspect. 2010 November;118(11):1614-1619.
4.
Figure 4

Figure 4. From: In Utero Exposure to Bisphenol A Shifts the Window of Susceptibility for Mammary Carcinogenesis in the Rat.

Cell proliferation in mammary glands of 100-day-old rats prenatally exposed to 250 μg BPA/kg BW or an equal volume of sesame oil (controls). (A) Ki-67 expression as an indicator of cell proliferation. Ducts from six biologically distinct samples (n = 6) were analyzed per treatment; magnification, 40×; bar = 100 μm. (B) Contingency table of cell proliferation data. (C) Ki-67 labeling index values (mean ± SE) as a percentage of the control group.
*p < 0.05 compared with controls.

Angela M. Betancourt, et al. Environ Health Perspect. 2010 November;118(11):1614-1619.
5.
Figure 5

Figure 5. From: In Utero Exposure to Bisphenol A Shifts the Window of Susceptibility for Mammary Carcinogenesis in the Rat.

Tumor incidence (proportion of rats that developed at least one tumor; A), tumor multiplicity (number of tumors per rat; B), and Kaplan-Meier survival curve with median time (days) to first tumor (C) in female offspring prenatally exposed to 250 μg BPA/kg BW or an equal volume of sesame oil (controls) and gavaged with a single dose of 30 mg DMBA/kg BW on PND100. Statistical analyses for tumorigenesis are described in “Statistical Methods.”
**p = 0.022, and #p = 0.070 compared with the control group.

Angela M. Betancourt, et al. Environ Health Perspect. 2010 November;118(11):1614-1619.

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