We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 2

1.
Figure 1

Figure 1. MSL3 chromodomain structure and specificity. From: Corecognition of DNA and a methylated histone tail by MSL3 chromodomain.

(a) Superposition of the Drosophila MSL3 with MOF (PDB: 2BUD) and HP1 bound to a H3K9me3 peptide (PDB:1KNE). (b) MSL3 surface electrostatic potential. (c) Specificity for nucleic acids. (d) DNA-dependent specificity for the H4K20 monomethyl-mark.

Daesung Kim, et al. Nat Struct Mol Biol. ;17(8):1027-1029.
2.
Figure 2

Figure 2. Structure of the MSL3 chromodomain in complex with DNA and the H4K20me1 peptide. From: Corecognition of DNA and a methylated histone tail by MSL3 chromodomain.

(a) Ribbon diagram of chromodomain (green) bound to DNA2 (yellow) and peptide (yellow); electron density from the refined |2Fo−Fc| map at 0.7 σ is in pink. The sphere within the aromatic cage is a water molecule. (b) Surface electrostatic potential of the chromodomain and its interactions with one peptide and two DNA duplexes. Residues (green) that constitute the primary (c) and secondary (d) DNA recognition surfaces. Residues Tyr31, Phe56, Trp59 and Tyr63 constitute an aromatic cage.

Daesung Kim, et al. Nat Struct Mol Biol. ;17(8):1027-1029.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk