Results: 4

1.
Figure 4

Figure 4. From: Clinical and immunologic predictors of influenza illness among vaccinated older adults.

Cytokine levels in PBMC stimulated with A/H3N2 virus pre- (0 wks) and post-vaccination (4-, 10- and 20-wks) are shown for the Vancouver site. In subjects who developed influenza illness, subjects who were PCR+ only (PCR+, n=3) and those who seroconverted ± PCR+ (Sero, n=6) were compared to subjects that did not develop influenza. Error bars represent standard error of the mean.

Zainab Shahid, et al. Vaccine. ;28(38):6145-6151.
2.
Figure 1

Figure 1. From: Clinical and immunologic predictors of influenza illness among vaccinated older adults.

A flow chart of the results of influenza surveillance is shown for the two study sites (University of Connecticut Health Center [UCHC] and Vancouver). Laboratory confirmation for influenza A/H3N2 cases (Flu A) and influenza B (Flu B) are shown indicating the numbers of seroconverters (sero only), PCR-confirmed (swab only), or both, for subjects reporting influenza-like illness (ILI) symptoms.

Zainab Shahid, et al. Vaccine. ;28(38):6145-6151.
3.
Figure 2

Figure 2. From: Clinical and immunologic predictors of influenza illness among vaccinated older adults.

PBMC stimulated 20 hours with live influenza virus and granzyme B (GzmB) activity measured in PBMC lysates stimulated with the A/H3N2 strain. Geometric mean GzmB levels represent combined data for the two study sites are shown for the pre- (0 wks) and post-vaccination (4- and 10-wks) time points in ILI subjects without laboratory confirmed A/H3N2 (No A/H3N2, n=77) and subjects who subsequently developed influenza after the 10-week time point (Flu A/H3N2, n=13). Error bars represent standard error of the mean.

Zainab Shahid, et al. Vaccine. ;28(38):6145-6151.
4.
Figure 3

Figure 3. From: Clinical and immunologic predictors of influenza illness among vaccinated older adults.

Serum antibody titers to the three vaccine strains and IFN-γ and IL-10 levels in PBMC stimulated with A/H3N2 virus pre- (0 wks) and post-vaccination (4-, 10- and 20-wks) are shown for the Vancouver site. In subjects who developed influenza illness (between 10 and 20 weeks post-vaccination), subjects who were PCR+ only (PCR+, n=3) and those who seroconverted ± PCR+ (Sero, n=6) were compared to ILI subjects that did not develop influenza A/H3N2 (n=54). (A) serum antibody titers to the three vaccine strains, and (B) IFN-γ and IL-10 levels, and the IFN-γ:IL-10 ratio in A/H3N2-stimulated PBMC are shown. Error bars represent standard error of the mean.

Zainab Shahid, et al. Vaccine. ;28(38):6145-6151.

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