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Figure 3

Figure 3. SPM results for the Video (Neutral vs Cocaine-cues) by Drug (Placebo vs MP) interaction (MP < PL).. From: Methylphenidate Attenuates Limbic Brain Inhibition after Cocaine-Cues Exposure in Cocaine Abusers.

Methylphenidate resulted in less metabolic changes than the Placebo and there were no regions were the differences were greater for Methylphenidate than for the Placebo conditions. Threshold of significance p<0.01 uncorrected, cluster size >200 voxels.

Nora D. Volkow, et al. PLoS One. 2010;5(7):e11509.
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Figure 4

Figure 4. SPM results for the voxel-wise correlation between changes in metabolism and changes in self-reports of cocaine craving (Neutral - Cocaine-cues) for the Placebo and the Methylphenidate conditions (p<0.005 uncorrected, cluster size >200 voxels).. From: Methylphenidate Attenuates Limbic Brain Inhibition after Cocaine-Cues Exposure in Cocaine Abusers.

For Placebo the correlations were negative (decreases in metabolism associated with increases in craving) whereas with Methylphenidate these were positive (increases in metabolism associated with increases in craving).

Nora D. Volkow, et al. PLoS One. 2010;5(7):e11509.

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