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Results: 4

1.
Figure 1

Figure 1. From: Extent of Small Bowel Resection Does Not Influence the Magnitude of Intestinal Adaptation in the Mouse.

Mean weight loss between operation and sacrifice in mice undergoing either 50% or 75% small bowel resection (SBR) or transection of the bowel with reanastomosis alone (sham). Mice in the 75% SBR group lost significantly more weight than shams and 50% SBR’s. N=10 for all groups * = p<.000001, ** = p<.0001.

Derek Wakeman, et al. J Pediatr Surg. ;45(6):1274-1279.
2.
Figure 4

Figure 4. From: Extent of Small Bowel Resection Does Not Influence the Magnitude of Intestinal Adaptation in the Mouse.

A Apoptotic indices measured by the number of apoptotic bodies per 100 crypts in mice undergoing either 50% or 75% small bowel resection (SBR) or transection of the bowel with reanastomosis alone (sham). Both SBR groups showed increased apoptotic rates PO compared to IO values. * = p<.000001, ** = p<.001.
B No statistical difference was found for the absolute change in apoptotic indices (PO-IO) between 50% SBR and 75% SBR groups (p=NS).

Derek Wakeman, et al. J Pediatr Surg. ;45(6):1274-1279.
3.
Figure 2

Figure 2. From: Extent of Small Bowel Resection Does Not Influence the Magnitude of Intestinal Adaptation in the Mouse.

Percent change in crypt depth and villus length for 50% (n=24) and 75% small bowel resection (SBR; n=10) groups. PO – postoperative measurements in the remnant bowel at 7 days following SBR; IO – intraoperative bowel removed at the time of intestinal resection. Percent Change = (PO-IO) / IO. No significant differences in magnitude of morphometric parameters of was observed between 50% SBR and 75% SBR groups (p=NS).

Derek Wakeman, et al. J Pediatr Surg. ;45(6):1274-1279.
4.
Figure 3

Figure 3. From: Extent of Small Bowel Resection Does Not Influence the Magnitude of Intestinal Adaptation in the Mouse.

A Proliferative rates measured by the percentage of BrdU staining cells per crypt in mice undergoing either 50% or 75% small bowel resection (SBR) or transection of the bowel with reanastomosis alone (sham). Both SBR groups showed increased proliferative rates compared to shams. * = p<.01, ** = p<.005.
B Percent change in rates of enterocyte proliferation after small bowel resection (SBR). No significant difference was found for the relative proliferative change between 50% SBR and 75% SBR groups after normalizing for sham values (p=NS).

Derek Wakeman, et al. J Pediatr Surg. ;45(6):1274-1279.

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