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1.
Fig. 4

Fig. 4. From: 1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression.

The concentration of IMCL and –CH2- / CH3 ratio for 25 subjects. (a) the IMCL concentration in the soleus muscle at rest is shown in panel a, and the intensity ratio (-(CH2)n-/-CH3) at TE 280 ms for both IMCL and EMCL is shown in panel b.

Jimin Ren, et al. Magn Reson Med. ;64(3):662-671.
2.
Fig. 3

Fig. 3. From: 1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression.

Soleus IMCL and EMCL MRS results (average ± standard deviation) measured at TE 280 ms and 7T (N = 25). (a) ΔH/H of IMCL -(CH2)n- signal; (b) chemical shift separation Δδ between IMCL and EMCL -(CH2)n- signals; (c) LW1/2 of creatine -CH3 and IMCL -(CH2)n- and -CH3 signals; (d) signal intensity of IMCL -(CH2)n- and -CH3 relative to creatine -CH3; (e) signal intensity of IMCL -CH=CH- relative to -CH3.

Jimin Ren, et al. Magn Reson Med. ;64(3):662-671.
3.
Fig. 7

Fig. 7. From: 1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression.

Experiments with phantoms. A two-compartment phantom in mimicking IMCL and EMCL in vivo, with vegetable oil droplets in mimicking “IMCL” and oil-soaked cylinder-shaped tissue roll in mimicking “EMCL”; The 1H MRS from phantom (a) at short TE of 20 ms (b) and long TE of 180 ms (c); (d) a different two-compartment phantom consisted of two oil-filled glass tubes in gel; The 1H MRS from phantom (d) at short TE of 20 ms (e) and long TE of 180 ms (f).

Jimin Ren, et al. Magn Reson Med. ;64(3):662-671.
4.
Fig. 2

Fig. 2. From: 1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression.

1H MR spectra collected from a single voxel in soleus muscle at 7T. The subject was a 25-year-old female with a high EMCL content, as shown by the dense white streaks on the MIP images, panel a. The region 0.7 – 1.7 ppm illustrates severely overlapping IMCL and EMCL signals on short TE spectrum (b, TE =20 ms, with WS) that are well-resolved with long TE strategy (c, TE = 280 ms, without WS). The scan time was 1.1 min for TE = 20 ms, and 4.3 min for TE = 280 ms, respectively.

Jimin Ren, et al. Magn Reson Med. ;64(3):662-671.
5.
Fig. 5

Fig. 5. From: 1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression.

Inversion-recovery 1H MR spectra and exponential curve fitting of the signal intensity of the bulk CH2 and terminal CH3 1H resonances for evaluation of IMCL and EMCL T1 relaxation time in soleus muscle. The red and blue traces in the spectra represent the Voigt lineshape fitting result and fitting residual, respectively. The T1 values derived from mono-exponential curve fitting were given in Table 1. Acquisition parameters: TR = 8 s, TE = 180 ms, SNA = 32, Scan time 4.3 min.

Jimin Ren, et al. Magn Reson Med. ;64(3):662-671.
6.
Fig. 1

Fig. 1. From: 1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression.

1H MR spectra collected from a single voxel in soleus muscle at 7T. The subject was a 32-year-old male. The selected volume is indicated by the white box on T2w images (a). Spectra with (panel b, short TE of 20 ms) and without (panel c long TE of 280 ms) water suppression are shown. Data were collected using a STEAM sequence. The scan time was 1.1 min for TE = 20 ms, and 4.3 min for TE = 280 ms, respectively. Definitions used for spectral resolution are shown in panel D. Resonance labels i: intramyocellular lipids (IMCL); e: extramyocellular lipids (EMCL); Cr3: total creatine methyl –CH3 group; Cr2: total creatine methylene –CH2 group; Ctn: carnitine; and Tau: taurine.

Jimin Ren, et al. Magn Reson Med. ;64(3):662-671.
7.
Fig. 6

Fig. 6. From: 1H MRS of Intramyocellular Lipids in Soleus Muscle at 7T: Spectral Simplification by Using Long Echo Times without Water Suppression.

Comparison of spectral resolution and the lineshape fitting in the fat region from 0.5 – 1.7 ppm acquired at different TEs from 30 to 280 ms from soleus muscle of a 27-yr healthy male. (a) experimental spectra; (b) the fitted spectra (red trace) with one symmetric Voigt lineshape for both EMCL and IMCL; (c) the fitted spectra (red trace) with one Voigt lineshape for IMCL but two for EMCL (grey trace); (d) plots of signal intensity Ln(S) vs. TE for the evaluation of T2 relaxation time for the bulk CH2 and terminal CH3 1H resonances of IMCL and EMCL. The derived T2 values were given in Table 1. The linear correlation coefficient was r = 0.999 for - (CH2)n- of IMCL and EMCL, 0.990 for EMCL -CH3, and 0.978 IMCL -CH3, respectively.

Jimin Ren, et al. Magn Reson Med. ;64(3):662-671.

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