Results: 3

1.
Figure 1

Figure 1. Bioluminescence imaging (BLI) of murine Nf1 OPG. From: CXCL12 Alone Is Insufficient for Gliomagenesis in Nf1 Mutant Mice.

BLI of (A) CXCL12 virus-injected mice (n = 5) and (B) Control virus-injected mice (n = 5). For each animal, BLI data were normalized to the initial post-injection BLI measurement.

Tao Sun, et al. J Neuroimmunol. ;224(1-2):108-113.
2.
Figure 3

Figure 3. AMD3100 did not attenuate optic pathway glioma (OPG) growth. From: CXCL12 Alone Is Insufficient for Gliomagenesis in Nf1 Mutant Mice.

(A) The volumes of the optic nerves were determined as described in Materials and Methods section. There was no difference in optic nerve volumes between mice treated with AMD3100 versus vehicle (PBS) control. (B) AMD had no effect on the mitotic index as measured by Ki-67 labeling. (C) AMD3100 had no significant effect on apoptosis as determined by TUNEL staining. (P > 0.5 in all analyses by two-tailed t-test)

Tao Sun, et al. J Neuroimmunol. ;224(1-2):108-113.
3.
Figure 2

Figure 2. Histological features of the single CXCL12-induced glioma. From: CXCL12 Alone Is Insufficient for Gliomagenesis in Nf1 Mutant Mice.

(A) The injection site from the single mouse diagnosed with glioma (TU: tumor) was characterized by increased cellularity with evidence for nuclear atypia and abnormal cell clusters. No remarkable hypercellularity was observed in non-tumor brain (NT: Non-Tumor) Scale bar = 20 μm. (B) CXCL12 expression was increased at the injection sites in both tumor-bearing and non-tumor-bearing brains. Scale bar = 80 μm. (C) Glial Fibrillary Acidic Protein (GFAP)-immunoreactive piloid cells were present within the hypercellular lesion in the brain tumor (asterisk). Only normal (stellate) astrocyte morphologies were found in the non-tumoral brain. Scale bar = 20 μm. (D) There was increased Olig2 expression within the hypercellular lesion in the brain tumor. Scale bar = 40 μm. (E) Infiltrating microglia were identified in brain tumor (IBA-1 staining). Scale bar = 40 μm. (F) A significant degree of angiogenesis was evident by Endoglin staining in the brain tumor. Scale bar = 40 μm. Positive cells appear brown in panels B–F.

Tao Sun, et al. J Neuroimmunol. ;224(1-2):108-113.

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