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Results: 5

1.
Figure 2

Figure 2. Relationship between mast cell counts and relative expression of CPA3 and tryptase. From: Involvement of mast cells in eosinophilic esophagitis.

Mast cell counts were determined by anti-tryptase IHC and correlated against the relative expression CPA3 (r = 0.68, p < 0.01)(A) and tryptase (r = 0.75, p < 0.01)(B) as determined by real-time PCR.

J. Pablo Abonia, et al. J Allergy Clin Immunol. ;126(1):140-149.
2.
Figure 4

Figure 4. Correlation of KITLG expression with intact and degranulated mast cell. From: Involvement of mast cells in eosinophilic esophagitis.

The normalized expression of KITLG is plotted against the maximum number of intact mast cells (r = 0.87, p < 0.01)(A) or degranulated mast cells (r = 0.86, p < 0.01) (B).

J. Pablo Abonia, et al. J Allergy Clin Immunol. ;126(1):140-149.
3.

Figure 3. Correlation of CPA3 expression with mast cell gene expression. From: Involvement of mast cells in eosinophilic esophagitis.

Correlations between microarray expression of CPA3 and mast cell related genes including: KIT (r = 0.82, p < 0.01), KITLG (r = 0.82, p < 0.01), PGDS (r = 0.91, p < 0.01), CCL26 (r = 0.81, p < 0.01), CXCL6 (r = 0.85, p < 0.01), CXCL1 (r = 0.63, p < 0.01)(A–F).

J. Pablo Abonia, et al. J Allergy Clin Immunol. ;126(1):140-149.
4.

Figure 5. Mast cell counts, gene expression, and mast cell transcriptome in patients treated with swallowed FP. From: Involvement of mast cells in eosinophilic esophagitis.

Maximum mast cell counts from normal, CE, EE, and compared to EE patients whom responded to fluticasone propionate (EE FP Resp), or who did not respond to fluticasone propionate therapy (EE FP Non-Resp). Response to treatment with swallowed FP was defined as ≤ 1 eosinophil per HPF (A). CPA3 expression on microarray (B). The mast cell related-transcriptome under varying conditions listed above (C).

J. Pablo Abonia, et al. J Allergy Clin Immunol. ;126(1):140-149.
5.

Figure 1. Mast cell counts in EE patient samples versus normal or chronic esophagitis samples. From: Involvement of mast cells in eosinophilic esophagitis.

The maximum number of tryptase positive mast cells per high power field in EE samples is increased (mean ± SEM) relative to NL, and CE patients (A). The maximum number of degranulated mast cells per high field is increased in EE relative to NL patients (B). Immunohistochemistry with anti-tryptase antibody in normal and EE patients (40×) (C). High power field (400×) from an EE patient demonstrating an intact mast cell with a dashed arrow and degranulated mast cells with solid arrows (D).

J. Pablo Abonia, et al. J Allergy Clin Immunol. ;126(1):140-149.

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