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Results: 5

1.
Figure 2

Figure 2. Genome-wide scan of K5275 using microsatellite (STR) markers and parametric linkage analysis. From: Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer.

A set of 330 polymorphic STR markers (325 genome-wide + 5 fine map) were used for genotyping and linkage analysis. The resulting LOD scores are indicated along the Y-axis and the chromosomal boundaries according to the Marshfield genetic map are indicated along the X-axis.

Deborah W. Neklason, et al. J Med Genet. ;47(10):692-699.
2.
Figure 3

Figure 3. Genome-wide scan of K5275 using SNP markers and nonparametric linkage analysis. From: Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer.

A set of 10,204 SNP markers were used for genotyping and 8,214 for linkage analysis. The resulting LOD scores are indicated along the Y-axis and the chromosomal boundaries according to the Marshfield genetic map are indicated along the X-axis.

Deborah W. Neklason, et al. J Med Genet. ;47(10):692-699.
3.
Figure 4

Figure 4. Chromosome 13q31 linkage analysis in K5275. From: Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer.

The left axis and black line report (multipoint) NPL score for the region with a maximum of 24.12. The right axis and grey line report the corresponding (multipoint) LOD score of 2.99 for the region. Nonparametric linkage analysis was performed with genotyped microsatellite markers and SNPs in the region of interest as indicated along the x-axis using the GENEHUNTER program.

Deborah W. Neklason, et al. J Med Genet. ;47(10):692-699.
4.
Figure 5

Figure 5. Linkage pedigree with haplotypes. From: Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer.

Individuals' numbers correspond to pedigree positions in Figure 1. Individuals with dark filled squares/circles were coded as affected. Individuals with grey filled squares/circles were coded as unknown. Individuals noted with (#) are the boarder line-affected cases that were run in duplicate as unknown or affected. The genetic marker and corresponding allele are listed in map order and represent the most informative markers within the region with the highest heterozygosity. The precise nonrecombinant boundaries sit between rs1854204 and rs1870836 (rs2077779), individual IV-14, and between D13S265 and rs745040 (rs2351871), individual III-18).

Deborah W. Neklason, et al. J Med Genet. ;47(10):692-699.
5.
Figure 1

Figure 1. K5275 Pedigree. From: Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer.

Trimmed pedigree representing the branches recruited for study. An asterisk indicates individuals with colonic phenotype information. Individuals with colorectal cancer are indicated as a dark filled circle/square with the age of diagnosis listed. Other cancers are listed with the age of diagnosis and cancer type. Individuals with tubular adenomas (TA) are marked with a half filled circle/square with the age at colonoscopy and size and histology of adenoma indicated. One or more siblings participated and no adenomas were identified, they are indicated as a diamond with the number of individuals noted in the diamond, and the age range of colonoscopy listed.

Deborah W. Neklason, et al. J Med Genet. ;47(10):692-699.

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