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Results: 4

1.
Figure 1

Figure 1. From: Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH.

CT imaging of the pelvis with contrast. A contrast enhancing mass was identified in the right intra-gluteal muscle and measured 4.4 × 3.8 cm (arrow)

Hatem Q. Al-Maghraby, et al. Cytojournal. 2010;7:5.
2.
Figure 4a-b

Figure 4a-b. From: Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH.

Histomorphologic features of dedifferentiated liposarcoma on excision. The excisional biopsy sections showed infiltrating malignant spindle cells with nuclear pleomorphism and mitoses. [a) Hematoxylin and eosin stain, ×600]. There were also areas of malignant spindle cells associated with ribbons of osteoid matrix [b) Hematoxylin and eosin stain, ×400]

Hatem Q. Al-Maghraby, et al. Cytojournal. 2010;7:5.
3.
Figure 3

Figure 3. From: Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH.

FISH studies performed on the FNA biopsy cell-block sections of dedifferentiated liposarcoma. The FISH studies demonstrated MDM2 (red signal) amplification in the atypical nuclei (arrow). In comparison, the adjacent normal cells showed no amplification of MDM2 (arrowhead). (The MDM2 probe is the red signal and the chromosome 12 centromere (CEP12) probe is the green signal)

Hatem Q. Al-Maghraby, et al. Cytojournal. 2010;7:5.
4.
Figure 2

Figure 2. From: Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH.

Cytomorphologic features of FNAB of dedifferentiated liposarcoma. a) DQ, ×400 (inset ×600); b) DQ, ×400 (inset ×200); c) Pap, ×400 (inset ×600); d) H&E, ×200). a) Loosely cohesive spindle cells with elongated atypical nuclei. Inset shows increased N/C ratio, hyperchromasia with tails of cytoplasm. b) Fragments of dense matrix with atypical spindle cells. Inset shows a multinucleated giant cell. c) Loosely cohesive spindle cells with enlarged hyperchromatic nuclei, cytoplasmic tails and coarse chromatin. d) Cell block sections shows cellular fragments of spindle cells with nuclear pleomorphism associated with dense eosinophilic matrix, consistent with osteoid. Inset shows areas of adipose tissue with scattered atypical cells

Hatem Q. Al-Maghraby, et al. Cytojournal. 2010;7:5.

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