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Fig. 1.

Fig. 1. From: Adult Neurogenesis Supports Short-Term Olfactory Memory.

Adult neurogenesis sculpts odor processing in the bulb. A: sensory odor information enters the olfactory system by binding to odorant receptors expressed on olfactory sensory neurons (OSNs). Odorant binding excites the OSNs, generating action potentials that evoke synaptic release onto not only mitral cells (MCs), but also periglomerular cells (PGs). Mitral cell firing patterns are sculpted by 2 general classes of inhibitory interneurons that include the PGs and granule cells (GCs). After refinement, odor information is relayed to target cells in the piriform cortex (CTX), where it is processed to influence behaviors. Continued renewal of newborn interneurons (NbPGs and NbGCs) is required to maintain levels of feedback inhibition onto MCs and short-term odor memory. Plus signs represent excitatory drive from MCs onto GCs; minus signs represent inhibition by GCs onto MCs. B: a general diagram modeling the potential nodes of the olfactory circuit involved in information processing and memory formation.

Benjamin R. Arenkiel. J Neurophysiol. 2010 June;103(6):2935-2937.

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