Results: 2

1.
Figure 2

Figure 2. From: Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration.

Schematic representation of cell adhesion signaling during EMT or cell scattering. Epithelial cell stimulation by TGFβ or other scattering factors triggers a transition from apical-basal to front-rear polarity. The PKL-PIX-PAK or GIT1-PIX-PAK complex is proposed to facilitate the breakdown of cell-cell adhesions as well as focal adhesion formation to promote mesenchymal cell motility, likely through local regulation of Arf6 and Rac1 activities.

Jianxin A Yu, et al. Cell Adh Migr. 2010 Jul-Sep;4(3):342-347.
2.
Figure 1

Figure 1. From: Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration.

A model for the Paxillin-PKL modulated signaling network. The physical engagement of integrins and growth factor receptors results in the activation of FAK and Src kinases. The adaptor protein paxillin recruits many scaffold and signaling components into focal adhesions. FAK/Src regulated tyrosine phosphorylation of paxillin and PKL facilitates dynamic protein-protein interaction with Rho GTPase regulators and effectors, thereby coordinating cytoskeleton organization and membrane remodeling. ECM, extracellular matrix; GF, growth factor; RTK, receptor tyrosine kinase; PM, plasma membrane.

Jianxin A Yu, et al. Cell Adh Migr. 2010 Jul-Sep;4(3):342-347.

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