Figure 1

Figure 1. Schematic of primate BMP2-induced SSEA-1+ cells. . From: Monkeying around with cardiac progenitors: hope for the future.

Epiblast cells in the embryo express the surface marker SSEA-1 as they differentiate and transiently express Oct4 and Mesp1 during the commitment to CPCs. Blin et al. show that using BMP2 to mimic the environment of epiblast cells, primate ES and iPS cells can be induced to differentiate into SSEA-1+ CPCs. Isolated BMP2-induced SSEA-1+ cells were multipotent CPCs that could be differentiated into endothelial cells, smooth muscle cells, and cardiomyocytes under different growth conditions. The SSEA-1+ cells were also multipotent in vivo upon transplantation into primate hearts.

Li Qian, et al. J Clin Invest. 2010 April 1;120(4):1034-1036.

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