Display Settings:

Items per page
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 6

1.
FIG. 4

FIG. 4. From: Investigation of Tumor Hyperpolarized [1-13C]-Pyruvate Dynamics Using Time-Resolved Multiband RF Excitation Echo-Planar MRSI.

Comparison of pyruvate and lactate characteristics between tumor voxels and liver voxels in TRAMP mice (circles) and normal mice (x’s, liver only). The lines connect data points for the same mouse, and each color also represents a different mouse.

Peder E. Z. Larson, et al. Magn Reson Med. ;63(3):582-591.
2.
FIG. 3

FIG. 3. From: Investigation of Tumor Hyperpolarized [1-13C]-Pyruvate Dynamics Using Time-Resolved Multiband RF Excitation Echo-Planar MRSI.

Large, late-stage heterogeneous tumor. a: Coronal T2-weighted FSE anatomical image showing a subset of the voxel locations. b: Metabolite curves for pyruvate, lactate, and alanine in each voxel. The green box highlights the liver, while the red highlights the tumor. c: Overlay images of the metabolite tSNR, all identically windowed. d: FWHM of the pyruvate and lactate signal. e: MT of pyruvate and lactate. The lactate tSNR, MT, and FWHM were larger within the tumor when compared to the normal tissue.

Peder E. Z. Larson, et al. Magn Reson Med. ;63(3):582-591.
3.
FIG. 6

FIG. 6. From: Investigation of Tumor Hyperpolarized [1-13C]-Pyruvate Dynamics Using Time-Resolved Multiband RF Excitation Echo-Planar MRSI.

Large, late-stage heterogeneous tumor. a: Axial T2-weighted FSE anatomical image. b: Hemotoxylin and eosin staining of a tumor cross-section at approximately the same location and orientation as (a). c,d: Pyruvate and lactate curves. No alanine was detected. e: FWHM of pyruvate and lactate. f: MT of pyruvate and lactate. There was less lactate, as well as greater lac MT and FWHM, along the left and anterior portions of the tumor (wide green arrows), corresponding to regions of less cellular density in (b). A lymph node metastasis can be seen (narrow red arrow) with very high lactate signal but very little pyruvate.

Peder E. Z. Larson, et al. Magn Reson Med. ;63(3):582-591.
4.
FIG. 5

FIG. 5. From: Investigation of Tumor Hyperpolarized [1-13C]-Pyruvate Dynamics Using Time-Resolved Multiband RF Excitation Echo-Planar MRSI.

a–c: Low cellular density of proliferating cancer cells. a: The coronal T2-weighted FSE anatomical image suggests an ill-defined tumor. b: Histology of tumor tissue with Ki-67 (cell proliferation) staining, shown in brown at 10x magnification, indicates the relatively low density of proliferating cancer cells and scattered areas of proliferation. c: Peak amplitude curves. d–f: Same as (a–c), but for a more aggressive tumor with a higher proliferative index, as indicated by dense Ki-67 staining in (e). The lactate normalized SNR is much larger in the more aggressive tumor, while the pyruvate is relatively similar. No alanine was detected in any of these voxels.

Peder E. Z. Larson, et al. Magn Reson Med. ;63(3):582-591.
5.
FIG. 2

FIG. 2. From: Investigation of Tumor Hyperpolarized [1-13C]-Pyruvate Dynamics Using Time-Resolved Multiband RF Excitation Echo-Planar MRSI.

Typical spectra and dynamic curves. a: The coronal T2-weighted FSE anatomical image shows the majority of the voxel locations. b: A typical single MRSI, acquired 25 sec following injection, demonstrates the spectral characteristics and typical SNR obtained with this method for 0.125-cc voxels. c–e: Dynamic curves for the metabolites. The liver (green box) contains all three metabolites and has a relatively large alanine signal. The tumor (red box) has very high lactate and no alanine, which is characteristic of these tumors. f: Dynamic curves from a normal mouse prostate and two TRAMP tumors. The lactate signal is greatly elevated with cancer and also is increased in the late-stage tumor.

Peder E. Z. Larson, et al. Magn Reson Med. ;63(3):582-591.
6.
FIG. 1

FIG. 1. From: Investigation of Tumor Hyperpolarized [1-13C]-Pyruvate Dynamics Using Time-Resolved Multiband RF Excitation Echo-Planar MRSI.

Multiband spectral-spatial excitation pulse with an echo-planar gradient and a 5 mm minimum slice thickness. a: RF pulse—real (solid) and imaginary (dashed) components—and accompanying gradient. b: Spectral profile, with specified bands (dashed lines) for pyruvate (pyr) of a 3.3° flip, a 20° flip for alanine (ala) and lactate (lac), and no excitation of pyruvate-hydrate (pyr-H2O). c: Spectral and spatial profile. Within the frequency range of interest, there is no chemical-shift misregistration. d: Pulse sequence. The spectral-spatial excitation was followed by a phase encoding gradient. A pair of adiabatic refocusing pulses is used for a B1–insensitive spin-echo (33), which occurs halfway through the EPSI readout gradient. The crushers around the adiabatic pulses and after the sequence are not shown, and the adiabatic pulse amplitude has been reduced for visualization.

Peder E. Z. Larson, et al. Magn Reson Med. ;63(3):582-591.

Display Settings:

Items per page

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk