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1.
Figure 2

Figure 2. From: Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels.

Elevated zero-maze: The combined MA-treated groups had reduced time to first entry to an open quadrant compared to the combined SAL-treated groups *p < 0.05.

Curtis E. Grace, et al. Int J Dev Neurosci. ;28(4):331-342.
2.
Figure 7

Figure 7. From: Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels.

Monoamine concentrations: DA and 5-HT in neonatally MA vs. SAL treated rats as a function of ADXA vs. SHAM surgery following the completion of behavioral testing (P106). A, C, E: monoamines in each region analyzed by group. B, D, F: main effect of drug with surgical conditions combined. *p < 0.05 combined MA-treated groups vs. combined SAL-treated groups.

Curtis E. Grace, et al. Int J Dev Neurosci. ;28(4):331-342.
3.
Figure 6

Figure 6. From: Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels.

Corticosterone levels following forced swim: Ls mean ± SEM (ng/ml) plasma CORT levels in rats following completion of behavioral testing (P106). Rats were euthanized 10 min following 30 min of forced swim. ADXA reduced CORT levels by 50.2% in both ADXA-SAL and ADXA-MA animals compared to their respective SHAM controls (A). The main effect of decreased CORT in ADXA animals is shown, regardless of surgery (B). ***p< 0.001 compared to SHAM controls.

Curtis E. Grace, et al. Int J Dev Neurosci. ;28(4):331-342.
4.
Figure 1

Figure 1. From: Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels.

Cincinnati water maze: The MA-treated groups show significant deficits in CWM performance regardless of surgery. A-C: Errors: D-F: latency to reach the escape platform. Learning curves for the SHAM and ADXA groups are shown separately in the left panels for each dependent measure and the main effect of drug treatment with surgical conditions combined are shown in the right-hand panel; **p< 0.01 or ***p < 0.001 combined MA-treated groups vs. combined SAL-treated groups.

Curtis E. Grace, et al. Int J Dev Neurosci. ;28(4):331-342.
5.
Figure 3

Figure 3. From: Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels.

Locomotor activity: Ls mean ± SEM total distance moved (cm) during a 60 min test session. A: Activity for SHAM and B: ADXA per treatment group. MA groups had reduced total distance (C inset) compared to SAL groups, and specifically MA groups had reduced total distance from 10-20 min and at 55 min (C). *p< 0.05, **p< 0.01, ***p< 0.001, all compared to SAL controls.

Curtis E. Grace, et al. Int J Dev Neurosci. ;28(4):331-342.
6.
Figure 5

Figure 5. From: Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels.

Morris water maze probe trials: Ls mean ± SEM average heading error to the former location of the platform 24 h after the last platform trial for each phase of MWM testing. There were no significant main effects of surgical condition and no interactions between drug and surgical condition. There were significant main effects of drug. For clarity the main effect of drug (with surgical conditions averaged together) are shown. *p < 0.05, **p < 0.01, ***p < 0.001 combined MA-treated groups vs. combined SAL-treated groups.

Curtis E. Grace, et al. Int J Dev Neurosci. ;28(4):331-342.
7.
Figure 4

Figure 4. From: Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels.

Morris water maze learning trials: Ls mean ± SEM path length (cm) averaged by day (4 trials/day) in neonatally MA vs. SAL-treated rats having ADXA or SHAM surgery. Left and middle panels show each treatment group as a function of surgical condition. Right panels show the main effect of drug treatment with the two MA-treated and two SAL-treated groups merged. Top row: acquisition; middle row: reversal; bottom row: shift. Panels C and F are shown by day to illustrate a significant drug × day interaction. Panel I is shown averaged across days to illustrate a drug main effect with no drug × day interaction. *p < 0.05, **p < 0.01, ***p < 0.001 combined MA-treated groups vs. combined SAL-treated groups.

Curtis E. Grace, et al. Int J Dev Neurosci. ;28(4):331-342.

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