Results: 4

1.
Figure 2

Figure 2. From: Multiplexed Assessment of the Southwest Oncology Group-Directed Intergroup Breast Cancer Trial S9313 by AQUA Shows that Both High and Low Levels of HER2 Are Associated with Poor Outcome.

Kaplan-Meier survival plot for DFS by AQUA ER (A), PR (B), and HER2 (C), all split into quartiles.

Malini Harigopal, et al. Am J Pathol. 2010 April;176(4):1639-1647.
2.
Figure 4

Figure 4. From: Multiplexed Assessment of the Southwest Oncology Group-Directed Intergroup Breast Cancer Trial S9313 by AQUA Shows that Both High and Low Levels of HER2 Are Associated with Poor Outcome.

A: Kaplan-Meier analysis of HER2 AQUA shows that both the top and bottom deciles have worse DFS than the middle 80% (log rank P = 0.012). B: Modeling the continuous hazard ratio against the log of the HER2 AQUA score shows a U-shaped relationship.

Malini Harigopal, et al. Am J Pathol. 2010 April;176(4):1639-1647.
3.
Figure 3

Figure 3. From: Multiplexed Assessment of the Southwest Oncology Group-Directed Intergroup Breast Cancer Trial S9313 by AQUA Shows that Both High and Low Levels of HER2 Are Associated with Poor Outcome.

A: Relationships between the log AQUA scores of ER, PR, and HER2 show that ER and PR are moderately highly correlated (Pearson r = 0.43, P < 0.0001; Spearman r = 0.48). B: The relationship between HER2 and ER is more complete, showing a correlation for low ER and HER2 that is lost at higher levels. The dotted line shows the lowest decile of HER2 AQUA scores. C: No relationship is seen between PgR and HER2.

Malini Harigopal, et al. Am J Pathol. 2010 April;176(4):1639-1647.
4.
Figure 1

Figure 1. From: Multiplexed Assessment of the Southwest Oncology Group-Directed Intergroup Breast Cancer Trial S9313 by AQUA Shows that Both High and Low Levels of HER2 Are Associated with Poor Outcome.

Distribution of expression of ER (A) and HER2 (B) in the study population is shown with log transformation of the data in the insets. C: Validation of multiplexing data is shown by comparison of single ER versus multiplexed (double) HER2 with ER on a control TMA using tissues from the Yale Pathology Archives. D: Single HER2 versus multiplexed (double) HER2 with ER. Similar results were seen for PgR and p53 (not shown). AQUA levels for each protein are presented on the y axis as arbitrary units.

Malini Harigopal, et al. Am J Pathol. 2010 April;176(4):1639-1647.

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