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1.
Figure 2

Figure 2. ATP8B1 mutant B6 mice lose substantial weight upon cholate feeding.. From: Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse.

Weight change per day in WT (A) and ATP8B1 mutant (B) mice of B6, 129, and F1 backgrounds after feeding of control (grey) or cholate (black) diet for 4–8 days; means and SEM are shown. N's for cholate diet: B6 (n = 8−13), 129 (n = 18−35), and F1 (n = 13−18); and control diet: B6 (n = 5−9), 129 (n = 22−29), and F1 (n = 11−16).

Sohela Shah, et al. PLoS One. 2010;5(2):e8984.
2.
Figure 8

Figure 8. Hepatic levels of triglycerides and cholesterol are influenced by diet and Atp8b1 mutation.. From: Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse.

Hepatic triglycerides and cholesterol in WT (A, C, E, and G) and mutant (B, D, F, and H) mice of B6, 129, and F1 background after cholate (black) and control (grey) diet for 4–8 days; mean and SEM are shown. N's for cholate diet: B6 (n = 4−10), 129 (n = 8−20), and F1 (n = 4−9); and control diet: B6 (n = 4−11), 129 (8−19), F1 (n = 4−8).

Sohela Shah, et al. PLoS One. 2010;5(2):e8984.
3.
Figure 1

Figure 1. ATP8B1 mutant B6 mice exhibit slower weight gain during the nursing period.. From: Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse.

Pup weight in WT and ATP8B1 mutant mice of B6, 129, and F1 backgrounds at: A) mid-nursing period (∼day 10) and B) weaning. Weights of mutant pups were normalized to those of WT and heterozygote littermates; means and SEM are shown. Range of N's: a) B6 (n = 14−56), 129 (n = 23−57), and F1 (n = 70−136) and b) B6 (n = 12−53), 129 (n = 23−58), and F1 (n = 50−138).

Sohela Shah, et al. PLoS One. 2010;5(2):e8984.
4.
Figure 7

Figure 7. ATP8B1 mutant B6 mice have larger livers than mutant 129 mice.. From: Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse.

Liver weight as a proportion of final body weight in WT (A) and ATP8B1 mutant (B) mice of B6, 129, and F1 backgrounds after feeding of cholate (black) or control (grey) diet for 4–8 days; means and SEM are shown. N's for cholate diet: B6 (n = 7−13), 129 (n = 18−35), and F1 (n = 13−18); and control diet: B6 (n = 5−9), 129 (n = 22−29), and F1 (n = 11−16).

Sohela Shah, et al. PLoS One. 2010;5(2):e8984.
5.
Figure 6

Figure 6. Composition of gallbladder bile after feeding of cholate-supplemented diet is influenced by ATP8B1 mutation and strain.. From: Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse.

Bile cholesterol, phospholipid, and bile salt levels in WT (A, C, & E) and ATP8B1 mutant (B, D, & F) mice of B6, 129, and F1 backgrounds after feeding of cholate diet for 4–8 days; means and SEM are shown. N's: B6 (n = 11−19), 129 (n = 39−52), and F1 (n = 19−22).

Sohela Shah, et al. PLoS One. 2010;5(2):e8984.
6.
Figure 4

Figure 4. Serum bilirubin concentration increases in ATP8B1 mutant mice upon cholate feeding.. From: Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse.

Proportion of WT (A) and ATP8B1 mutant (B) mice of B6, 129, and F1 backgrounds with normal (light grey), moderately elevated (medium grey), and highly elevated (black) serum bilirubin levels in after feeding cholate or control diet for 4–8 days. N's for cholate diet: B6 (n = 5−8), 129 (n = 30−31), and F1 (n = 13−25); and control diet: B6 (n = 10−13), 129 (n = 39−48), and F1 (n = 18−23).

Sohela Shah, et al. PLoS One. 2010;5(2):e8984.
7.
Figure 5

Figure 5. Serum Bile salts levels are higher in ATP8B1 mutant mice.. From: Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse.

Serum bile salt levels in WT (A) and Atp8b1 mutant (B) mice of B6, 129, and F1 backgrounds at baseline (light grey) and after feeding of cholate (black) or control (medium grey) diet for 4–8 days; means and SEM are shown. N's at baseline: B6 (n = 9−15), 129 (n = 48−43), and F1 (n = 43−45). N's for cholate diet: B6 (n = 7−13), 129 (n = 18−35), and F1 (n = 13−18); and control diet: B6 (n = 5−9), 129 (n = 22−29), and F1 (n = 11−16).

Sohela Shah, et al. PLoS One. 2010;5(2):e8984.
8.
Figure 3

Figure 3. Atp8b1 mutation results in lowered serum cholesterol and increased serum alkaline phosphatase (sALP) levels in B6 mice.. From: Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse.

Serum cholesterol and alkaline phosphatase levels in WT (A, C) and mutant (B, D) mice of B6, 129, and F1 backgrounds at baseline (light grey) and after feeding of cholate (black) or control (medium grey) diet for 4–8 days; means and SEM are shown. N's at baseline: B6 (n = 7−15), 129 (n = 42−66), and F1 (n = 21−36); N's for cholate diet: B6 (n = 5−12), 129 (n = 15−29), and F1 (n = 6−19) and for control diet: B6 (n = 5−12), 129 (n = 18−29), and F1 (n = 11−18).

Sohela Shah, et al. PLoS One. 2010;5(2):e8984.

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