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Results: 5

1.
FIGURE 2

FIGURE 2. Study Timeline. From: The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin.

At all study visits, subjects underwent phlebotomy for plasma LPC, LPA, autotaxin & RBC fatty acids. Phlebotomies occurred before ingestion of the study agent at each study visit

RC Block, et al. Prostaglandins Leukot Essent Fatty Acids. ;82(2-3):87-95.
2.
FIGURE 5

FIGURE 5. From: The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin.

The values for EPA & DHA species of LPC and LPA are represented as the % increase in the proportion of each of total LPC and LPA, respectively. The values for RBC EPA & DHA are represented as the % increase in the proportion of each of total RBC fatty acids. The vertical lines indicate 1 standard deviation.

RC Block, et al. Prostaglandins Leukot Essent Fatty Acids. ;82(2-3):87-95.
3.
FIGURE 4

FIGURE 4. Lysophosphatidic (LPA) Acid Species Concentrations. From: The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin.

A diamond indicates that a significant difference exists between LPC or LPA concentrations after 28 days of EPA+DHA (time point 3) compared to baseline. A star ☆ indicates that a significant difference (p<.05) exists between LPC or LPA concentrations at the final study visit compared to baseline. Note that the scale for each LPC and LPA varies due to differences in baseline concentrations. Error bars represent 95% confidence intervals. Differences in means were detected using the paired t-test.

RC Block, et al. Prostaglandins Leukot Essent Fatty Acids. ;82(2-3):87-95.
4.
FIGURE 3

FIGURE 3. Lysophosphatidylcholine (LPC) Species Concentrations. From: The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin.

A diamond indicates that a significant difference exists between LPC or LPA concentrations after 28 days of EPA+DHA (time point 3) compared to baseline. A star ☆ indicates that a significant difference (p<.05) exists between LPC or LPA concentrations at the final study visit compared to baseline. Note that the scale for each LPC and LPA varies due to differences in baseline concentrations. Error bars represent 95% confidence intervals. Differences in means were detected using the paired t-test.

RC Block, et al. Prostaglandins Leukot Essent Fatty Acids. ;82(2-3):87-95.
5.
FIGURE 1

FIGURE 1. Schematic Representation of Hypothesized LPC and LPA Production Pathways. From: The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin.

Composite phospholipid metabolic pathways derived from in vitro and in vivo investigations. [1] EPA/DHA supplementation may affect: 1) plasma content of LPC and the pathway(s) leading to its synthesis; 2) plasma content of LPA and the pathway(s) leading to its synthesis. The dashed line to autotaxin indicates that the potential for aspirin to inhibit this pathway. LPP (lipid phosphate phosphatase) and acylglycerol kinase (AGK) regulate the balance of LPA and monoacylglycerol.

RC Block, et al. Prostaglandins Leukot Essent Fatty Acids. ;82(2-3):87-95.

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