Results: 3

1.
Figure 2

Figure 2. From: COMT genotype affects prefrontal white matter pathways in children and adolescents.

Aligned dot plots for Fractional Anisotropy (FA), Axial Diffusivity (AD), and Radial Diffusivity (RD) by gene group. Larger horizontal bars indicate group means, and smaller horizontal bars above means indicate standard error of the mean. Val-allele homozygotes were significantly different from one or both of the other gene groups (for more detail refer to Table 2) except FA in the GCC, for which the three groups did not differ significantly.

Moriah E. Thomason, et al. Neuroimage. ;53(3):926-934.
2.
Figure 3

Figure 3. From: COMT genotype affects prefrontal white matter pathways in children and adolescents.

Past research supports an inverted U-shaped relation between performance measures and dopamine level in the PFC (Goldman-Rakic et al., 2000; Williams-Gray et al., 2007). In the present study we found that fractional anisotropy (FA) has an inverse relation with expected dopamine level. Because higher FA is correlated with developmental maturation 1, 2 (see Discussion), this result suggests that val-allele homozygotes are in the optimal position on this curve.

Moriah E. Thomason, et al. Neuroimage. ;53(3):926-934.
3.
Figure 1

Figure 1. From: COMT genotype affects prefrontal white matter pathways in children and adolescents.

3D Visualization of the targeted fiber tracts. The top and bottom-left panels show, in a randomly selected participant, the major fiber tracts of interest with strong projections to prefrontal cortical regions. ATR = anterior thalamic radiation (left: light orange; right: yellow); GCC = genu of the corpus callosum (light green); IFO = inferior frontal occipital fasciculus (left: blue; right: purple); and UNC = uncinate fasciculus (left: red; right: orange). The bottom-right panel shows the control fiber tract tested to examine the regional specificity of COMT genotype differences: SCC = splenuim of the corpus callosum (dark green).

Moriah E. Thomason, et al. Neuroimage. ;53(3):926-934.

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