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1.
Figure 1

Figure 1. Proposed etiology of how the environmental impacts on disease. From: EPIGENETIC TRANSGENERATIONAL ACTIONS OF ENVIRONMENTAL FACTORS IN DISEASE ETIOLOGY.

The cascade of molecular and physiological processes following an environmental exposure to promote disease is shown.

Michael K. Skinner, et al. Trends Endocrinol Metab. ;21(4):214-222.
2.
Figure 2

Figure 2. Role of the germ line in epigenetic transgenerational inheritance. From: EPIGENETIC TRANSGENERATIONAL ACTIONS OF ENVIRONMENTAL FACTORS IN DISEASE ETIOLOGY.

(i) An environmental factor acts on the F0 generation gestating female to influence (ii) the developing F1 generation fetus and alter gonadal development to reprogram the primordial germ cell DNA methylation. (iii) This altered DNA methylation in the germ line becomes permanently programmed similar to an imprinted-like gene and is transferred through the germ line to subsequent generations. The embryo generated from this germ line starts with an altered epigenome that (iv) affects developing somatic cells and tissues to have an altered transcriptome. This altered somatic cell transcriptome can then promote adult onset disease associated with the transgenerational phenotype.

Michael K. Skinner, et al. Trends Endocrinol Metab. ;21(4):214-222.

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