Results: 4

1.
Figure 2.

Figure 2. From: An In Vitro Intact Globe Expansion Method for Evaluation of Cross-linking Treatments.

CP (lines and open symbols, left axis) and its rate of change (filled bars, right axis) measured before and during imposition of an IOP of 22 mm Hg in 10 kit eyes. The size of the eyes increased after the transition from no pressure to low pressure. The rate of change was greatest during the first 15 minutes. Most changes occurred within the first 30 minutes of shape restoration. Results for CP were exemplary of all globe dimensions during the first hour of low pressure.

Matthew S. Mattson, et al. Invest Ophthalmol Vis Sci. 2010 June;51(6):3120-3128.
2.
Figure 1.

Figure 1. From: An In Vitro Intact Globe Expansion Method for Evaluation of Cross-linking Treatments.

(A) Apparatus for controlling IOP during intact globe expansion experiments. (Not to scale: The eye is approximately 14 cm in diameter, and the height of the reservoir ranges from 30 to 116 cm.) The height of the saline reservoir generates a hydrostatic pressure that is transferred to the eye through the hypodermic needle on opening the valve. A bath of DPBS maintains the equilibrated extent of hydration of the tissue. Digital photographs are taken throughout the 24 hours of testing. (B) Ocular dimensions are measured with a program written in commercial software (MatLab; The MathWorks, Natick, MA).

Matthew S. Mattson, et al. Invest Ophthalmol Vis Sci. 2010 June;51(6):3120-3128.
3.
Figure 4.

Figure 4. From: An In Vitro Intact Globe Expansion Method for Evaluation of Cross-linking Treatments.

Change of corneal dimensions with time (t = 0 at the end of the restoration period). Left: rabbit kit eyes subjected to low (22 mm Hg) and high (85 mm Hg) pressures; *the first time point at which the two differed significantly. The cornea was more susceptible to creep than was the sclera (compare to scaling of Fig. 3). The kit cornea expanded to nearly a plateau level at low pressures; at high pressure, it expanded continuously. Middle: kit and adult rabbit eyes subjected to high pressures (85 mm Hg); *the first time point at which the two differed significantly. The cornea of the adult eye resisted expansion compared to that of the kit eye. Right: rabbit kit corneas subjected to high pressure after treatment. Dextran controls expanded similarly to untreated kit eyes. Rib/UVA-treated corneas resisted corneal expansion. Glyceraldehyde-treated eyes resisted any expansion. Asterisk and R, G, and T: significant differences as described in Figure 3.

Matthew S. Mattson, et al. Invest Ophthalmol Vis Sci. 2010 June;51(6):3120-3128.
4.
Figure 3.

Figure 3. From: An In Vitro Intact Globe Expansion Method for Evaluation of Cross-linking Treatments.

Change of scleral dimensions with time (t = 0 at the end of the restoration period). Left: rabbit kit eyes subjected to low (22 mm Hg) and high (85 mm Hg) pressures; *the first time point at which the two differed significantly (P < 0.05, Student's t-test). At low pressure, the rabbit kit sclera remained stable; at high pressure, the sclera expanded. Middle, rabbit kit eyes and adult rabbit eyes subjected to high pressures (85 mm Hg); *the first time point at which the two differed significantly. The sclera of kit eye expanded much more than that of the adult eye. Right: rabbit kit eyes subjected to high pressure after treatment. Dextran control specimens expanded similarly to untreated kit eyes. Riboflavin/UVA (Rib/UVA) treatment was intentionally localized to the cornea, and so it had little effect on scleral expansion. Glyceraldehyde-treated eyes resisted expansion. R, the first point at which the difference between riboflavin/UVA treatment and the dextran control is statistically significant; G, the first point of significant difference between glyceraldehyde treatment and the control; and T, the first point of significant difference between the two treatments.

Matthew S. Mattson, et al. Invest Ophthalmol Vis Sci. 2010 June;51(6):3120-3128.

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